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An incredible revolution
is happening in the world

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of health care

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that some claim could be the cure
that doctors and patients

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desperately need.

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Artificial intelligence, or AI.

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Basically, making computers think.

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Artificial intelligence could
really revolutionise health care.

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Allow us to understand
our patients better,

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to develop new diagnostic tools,
even new treatments.

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All of us could benefit
from this change, which is driven

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by the private tech industry.

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They're saying that we're going
to do with health care what Google

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did with information.

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One grand ambition is to get AI
computers to diagnose diseases

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as well as a human
doctor, or better.

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This could relieve pressure
from the NHS and help bring

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good health care to parts of
the world where doctors are scarce.

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So what's not to like?

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But the race to get ahead
in the market involves

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a major culture clash.

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You have the technology world,
the Silicon Valley,

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move fast, break stuff,
and then you have the diligent,

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evidence-based, do no
harm health care system.

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Some even see AI's roll-out
as potentially dangerous.

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how to regulate it, we don't know
how to prove it's effective.

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Just because we can do something
doesn't mean we should.

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The stakes could not be higher,
and this is a revolution

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that is happening right now.

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A seismic disruption
for the NHS is on the cards

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and, in a blind trial, we will see
AI being put to the test.

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So can the machines beat
the doctors, and should we trust

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them if they can?

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The British health system,
with its easily lost handwritten

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notes, isn't exactly
renowned for its IT.

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I haven't seen one of
these for a long time!

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But then, I don't work for the NHS,
which is the biggest purchaser

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of new fax machines
in the entire world.

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And sometimes our beloved NHS
really feels every bit 70 years old.

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But maybe not for much longer.

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And that is thanks
to artificial intelligence,

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using algorithms to get computers
and machines to automate some

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of the brain work
usually done by doctors.

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There is, in fact,
a health tech gold rush going on.

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Loads of new smart apps promise
to help us keep fit and well,

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and the corporate giants
are pouring vast sums

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of money into AI.

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Apple wants to use your phone
sensors to monitor your health.

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Google's Deep Mind uses AI to spot
serious eye disease.

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IBM is working on cancer diagnosis.

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The profits are potentially
eye-watering, but some people

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are seriously worried.

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In science, you don't believe
anything until it's proven

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and, in medicine, you're
especially cautious.

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This isn't some online shopping
suggestions or AI recommending

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you a film you might like to watch -
this can be life or death.

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But in the very competitive tech
industry, it's quite normal

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for companies to race
to get their products out.

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To witness this phenomenon
from the inside, we've had unique

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access to one tech
company in particular -

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Babylon Health.

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Based in London, Babylon have hired
an international team of top

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computer scientists and doctors
with a mission to use AI and mobile

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phones to transform
the way we access GPs.

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British entrepreneur
Dr Ali Parsa is their CEO.

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We started Babylon
to see if you can make

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health care accessible, affordable
and put it in the hands of every

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human being on Earth.

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To take most of the health care
most people need and deliver

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it to them on devices
they already have.

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2018 is set to be a big year
for Babylon, who want to prove

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that their artificial intelligence,
programmed to understand symptoms

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and offer health advice,
is a match for human doctors.

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We're saying that we are
going to create a machine

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that can eventually hopefully tell
you about your disease as accurately

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as a doctor can, that can give
you your treatment better

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than most doctors can,
that can look faster,

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cheaper, at variations of symptoms,
billions of variations of symptoms,

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as well as if you had one
of the best doctors in the world

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in your pocket.

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That's the big vision,
but you can use Babylon's

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smartphone app right now.

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Like others on the market,
such as Ada and Your.MD,

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it uses AI to let you check
your symptoms when you feel unwell.

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And if you want,
it will book you in to see

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one of their doctors privately.

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So I can see you've completed
our AI assessment.

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And in London, there's a scheme
that offers Babylon's AI

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and its doctors on the NHS,
entirely free.

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This is Lillie Road
in Fulham, west London.

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To look at it, you'd have little
clue that this nondescript GP

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surgery is at the centre
of a hi-tech venture.

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In late 2017, it partnered
with Babylon to set

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up a new NHS GP service -

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GP At Hand.

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Any adult who lives or works
in inner London can download

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Babylon's GP At Hand app and use
it to switch from their normal GP

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to being registered
here at Lillie Road.

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So many Londoners have done
this that this is now one

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of the fastest-growing GP
surgeries in the country

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with some 30,000 patients.

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But most of those people will never
actually come here to see a doctor,

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and that's because the only
way to initiate contact with

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GP At Hand is online.

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Although appointments are available
at one of their clinics

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if you really need to see
a doctor face-to-face.

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We can be open 24 hours a day,
seven days a week.

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That is three times as much coverage
as your GP has for exactly the same

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price and, more importantly, often,
you have to wait days or weeks

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to see a GP. With us, you're
seen within minutes.

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That is the beauty,
the amazing thing about technology.

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Dan Smith is one of many
who downloaded the app.

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One of the big restrictions
that people have around primary care

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is about time.

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I run my own business,
I have a two-year-old daughter,

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I don't have time.

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So being able to just pick the phone
up and have an appointment

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whenever you want to
I think's really important.

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Using GP At Hand is
pretty straightforward.

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You just put in, "I have a
headache," and then it will just

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take you through a list
of questions.

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The app uses AI to check
patients' symptoms and advise

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whether they need to see a doctor -
a process called triage.

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If it says "See a doctor,"
you can just go straight

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in and have a video appointment,
typically within ten minutes.

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You said that you're not
feeling very well.

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I can see that you've used
the triage chat today.

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Dr Zahra Damji is one of around 200
GPs employed by Babylon in the UK.

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Could you just tell me a bit
more about how you've been feeling?

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I'm able to spend a lot of time
seeing patients digitally,

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perhaps more so than I would
have done if I was just working

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within that traditional model,
and actually having more patient

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contact means that, as a GP,
I'm happier because, ultimately,

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what I want is to see patients.

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Babylon's GP At Hand app not only
gives patients triage advice,

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it also provides diagnostic
information to the online GP.

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The information comes
up in a list format for us,

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so we try to work out
from that information

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what we predict the diagnosis
for them could be,

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but we're already one step
ahead because we've got

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all of that information
in front of us.

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It also allows us to focus
our questions better.

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Have a feel of your neck for me.
If you just kind

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of put your finger
across your jawline,

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just press all the way round.

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It's a slightly strange experience,
speaking to a doctor on the phone

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rather than face-to-face.

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Stop. Stop, keep it right there.

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OK, that's quite a good view.

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Dan has certainly put
the service through its paces.

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I suddenly started feeling
a strange feeling in my face.

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I looked in the mirror
and half my face had dropped.

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And the immediate fear you have is,
"Am I having a stroke?"

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I can hear your speech is slightly
affected because of your mouth.

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I had a video call with a doctor
within three minutes,

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and he did a couple of basic tests,
and he quickly eliminated

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it being a stroke
and, because of the way

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that it was presenting,
that it was Bell's palsy.

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It tends to get better.
It's quite a dramatic problem

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to have at the moment.

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It meant I didn't have to rush
down to A&E and I could just

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take some steroids and
some painkillers.

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Being able to speak to a doctor
and have them to reassure

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you in minutes
I thought was wonderful.

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Talking to a doctor
via your smartphone certainly feels

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a lot more efficient than schlepping
down to the local GP and waiting

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in a queue.

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But that is not
artificial intelligence.

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Where AI comes into all
of this is in the symptom checker.

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This is the first thing that
you see when you open up one

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of these kinds of app,
it's where the patient types

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in their symptoms to what's
known as a chatbot.

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At this point, there is no
doctor involved at all.

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The computer is doing
all of the thinking.

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It's working out what might be wrong
with you and giving you information

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about what to do next.

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And if the AI is working well, it
will filter out all of the people

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with non-serious conditions,
leaving human GPs to treat

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the patients who really
need their expertise.

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So how does this kind of AI work?

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Dr Saurabh Johri leads
Babylon's AI team.

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What we're trying to do
is essentially replicate the kind

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of decision-making process
that a human doctor takes

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when they try and
diagnose a patient.

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If a user is sick,
what we're trying to do is reason

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about what may be the
underlying condition.

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For their AI to do this, to reason,
it will have to master

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three key skills.

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First, it has to become
as knowledgeable as a human doctor.

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Then it must learn to talk to you,
ideally in a nice,

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human-like way.

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Finally, it must be able
to use all that to deduce

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what might be wrong.

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And that's what we're trying
to build, to replicate kind

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of human decision-making in
terms of medical diagnosis.

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It's not easy.

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Babylon's team have trained
their machines to hoover up as much

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medical knowledge as possible.

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We have created systems
that can read papers,

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they can read web pages,
and they are much faster than us.

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Imagine you had a magical box
that you could put a book

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in and it was like eating the book
and understanding it.

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That's what it does.

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But hoovering information
isn't enough.

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The knowledge has to be organised
into a knowledge graph -

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a vast web of interconnections.

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And then the chatbot must be taught
to interpret the meaning

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of what the patient tells it.

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To a machine, a word
is just a string of characters,
there's no further meaning to it.

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In order to determine
what something means,

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it is important to learn
what it is similar to.

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The AI computer tries to capture
the similarity between words

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in a kind of mathematical map.

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For instance, words
like headache and migraine,

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with similar meanings,
go in the head region.

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If I can arrange things in a way
that the computer can easily figure

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out the two things are similar,
then you're taking a large step

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towards the computer actually
understanding what the word means.

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A map of phrases you might say
to the chatbot works in exactly

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the same way.

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Those that mean something similar
belong in the same part of the map,

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which helps the chatbot decide
what questions to ask you next.

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We are at ground zero today.

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I bet, in two years' time,
maybe five years' time -

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but it certainly isn't
anything longer than that -

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machines can speak any language
in the world in any local accent

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and understand any dialect.

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That is a game changer.

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The computing powers,
the data sciences,

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are now becoming sophisticated
enough for us to be able to do

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things that only a few years ago
we used to dream about.

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Imagine everyone having powerful
clinical artificial intelligence

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in their pocket.

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So how can I help you today?

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I've got a bad headache.

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Headaches are really common...

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Since their launch,
Babylon have invested tens

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of millions of pounds
on research and development.

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According to the World Health
Organization,

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we need at least five
million more doctors.

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00:14:53,000 --> 00:14:55,840
They're trying to edge
out their competitors to be the

241
00:14:55,840 --> 00:15:00,920
go-to health app in the potentially
highly lucrative global market.

242
00:15:01,520 --> 00:15:03,080
But what about the rest
of the world?

243
00:15:03,080 --> 00:15:06,200
They've signed up patients
from Britain to Rwanda

244
00:15:06,200 --> 00:15:09,360
and partnerships from
China to Saudi Arabia.

245
00:15:12,280 --> 00:15:17,360
Such is the current buzz about AI's
potential to help us do many things

246
00:15:17,480 --> 00:15:21,640
better, faster and cheaper
that the British Government are keen

247
00:15:21,640 --> 00:15:24,080
to get in on the act.

248
00:15:24,080 --> 00:15:28,120
The United Kingdom will incubate
a whole new industry around AI

249
00:15:28,120 --> 00:15:30,160
in health care.

250
00:15:30,160 --> 00:15:34,840
But for all the excitement,
some people have serious concerns

251
00:15:34,840 --> 00:15:38,680
about how this market functions.

252
00:15:38,680 --> 00:15:43,760
I think there is an inherent risk
in the hype that is required

253
00:15:44,760 --> 00:15:47,840
to attract the kind of venture
capital that these companies

254
00:15:47,840 --> 00:15:52,040
who are developing novel AI
technologies are reliant on to get

255
00:15:52,040 --> 00:15:54,800
themselves off the ground,
in many cases.

256
00:15:54,800 --> 00:15:58,800
There is a risk that behind the hype
there won't turn out

257
00:15:58,800 --> 00:16:00,720
to be enough substance.

258
00:16:00,720 --> 00:16:03,480
I'm under no doubt that this
potentially could really

259
00:16:03,480 --> 00:16:06,760
revolutionise health care,
I'm really excited about that.

260
00:16:06,760 --> 00:16:11,400
But the real tragedy
here would be if we over-promise

261
00:16:11,400 --> 00:16:13,920
and then funding dries
up and we're unable to develop

262
00:16:13,920 --> 00:16:16,600
these tools, and therefore
patients miss out on them.

263
00:16:19,920 --> 00:16:23,160
Personally, I find it
hard not to be excited

264
00:16:23,160 --> 00:16:27,240
about the possibilities that AI
offers for radically

265
00:16:27,240 --> 00:16:29,280
transforming health care.

266
00:16:29,280 --> 00:16:32,520
But it's also really important
that we don't allow the hype

267
00:16:32,520 --> 00:16:35,760
around AI, which is
currently pretty massive,

268
00:16:35,760 --> 00:16:38,600
to tarnish its true potential.

269
00:16:38,600 --> 00:16:40,840
And that means that the people
who are involved here

270
00:16:40,840 --> 00:16:45,760
should be really responsible about
the claims that they're making.

271
00:16:45,760 --> 00:16:49,400
And what's more, we should remember
that changing how people interact

272
00:16:49,400 --> 00:16:53,040
with a trusted institution
like the NHS is never

273
00:16:53,040 --> 00:16:54,760
going to be easy.

274
00:17:00,360 --> 00:17:05,000
Some critics have taken aim
at Babylon's GP At Hand service,

275
00:17:05,000 --> 00:17:09,400
worried less about the AI
and more about its rapid growth

276
00:17:09,400 --> 00:17:13,560
and impact on normal NHS GPs.

277
00:17:13,560 --> 00:17:17,040
I'm a GP from East London,
and I've come here because

278
00:17:17,040 --> 00:17:20,240
I'm furious for my patients,
my family and myself

279
00:17:20,240 --> 00:17:23,720
about the privatisation in the NHS.

280
00:17:23,720 --> 00:17:28,680
In protests in London in 2018,
a range of concerns are voiced.

281
00:17:29,000 --> 00:17:32,200
But we're not against artificial
intelligence when it

282
00:17:32,200 --> 00:17:33,880
helps patient care.

283
00:17:33,880 --> 00:17:36,680
But we're really worried
that this system is set to undermine

284
00:17:36,680 --> 00:17:38,000
front line practice.

285
00:17:38,000 --> 00:17:42,080
There are lots of good, I've no
doubt, digital interventions,

286
00:17:42,080 --> 00:17:43,440
but this is not one.

287
00:17:46,480 --> 00:17:51,360
Every GP is paid a fee by the NHS
for each of its patients,

288
00:17:51,760 --> 00:17:56,160
so when London GPs like Dr Jackie
Applebee lose patients to

289
00:17:56,160 --> 00:17:59,120
GP At Hand, they lose funding, too.

290
00:18:03,120 --> 00:18:06,160
So the big concerns that motivated
the protest against GP At Hand

291
00:18:06,160 --> 00:18:09,080
was our real fear that it's going
to destabilise general practice.

292
00:18:09,080 --> 00:18:12,880
Our patients are leaving,
taking their capitation fee from us

293
00:18:12,880 --> 00:18:15,920
to GP At Hand so that we can't
provide the care that we want

294
00:18:15,920 --> 00:18:18,520
to provide to the whole
of our patient population.

295
00:18:20,400 --> 00:18:24,640
GP At Hand capitalises on the fact
that people can now register

296
00:18:24,640 --> 00:18:27,280
with practices far away from home.

297
00:18:28,600 --> 00:18:31,960
It's partly this loophole
that allows Babylon to attract

298
00:18:31,960 --> 00:18:36,240
digitally savvy young Londoners away
from their old doctors.

299
00:18:37,880 --> 00:18:40,960
GP leaders hadn't seen this coming.

300
00:18:42,320 --> 00:18:44,960
GP At Hand certainly burst
onto the scene in London last year

301
00:18:44,960 --> 00:18:48,000
and took us all by surprise
because people didn't realise

302
00:18:48,000 --> 00:18:50,440
that there was this loophole
in the contractual mechanisms

303
00:18:50,440 --> 00:18:52,840
of all GP surgeries
that they could adopt.

304
00:18:52,840 --> 00:18:55,920
But they did, they saw it,
and they grabbed it.

305
00:18:55,920 --> 00:18:58,600
When you take the fit,
well people out of a practice

306
00:18:58,600 --> 00:19:01,000
and the money goes with them,
you're left with far

307
00:19:01,000 --> 00:19:02,800
less money to look
after the really sick,

308
00:19:02,800 --> 00:19:05,640
frail people that leaves
the practice in jeopardy.

309
00:19:05,640 --> 00:19:08,600
And if that practice goes under,
what's going to happen
to those patients?

310
00:19:08,600 --> 00:19:10,760
That is a real risk
to the individuals

311
00:19:10,760 --> 00:19:12,160
and to their communities.

312
00:19:16,040 --> 00:19:19,800
Unease about GP At Hand,
which hopes soon to expand

313
00:19:19,800 --> 00:19:23,360
nationwide, is not just about money.

314
00:19:25,240 --> 00:19:28,640
Something that really concerns me
about the GP At Hand type model

315
00:19:28,640 --> 00:19:31,080
is that, on their website, they say,
if you're pregnant,

316
00:19:31,080 --> 00:19:33,680
if you're mentally ill,
if you've got a complex long-term

317
00:19:33,680 --> 00:19:35,960
condition, we might not
be the best service for you.

318
00:19:35,960 --> 00:19:38,600
So what they're doing
is they're creating a two-tier

319
00:19:38,600 --> 00:19:41,560
health care service and, if this
starts to come in, and more and

320
00:19:41,560 --> 00:19:46,560
more practices start to do that,
then we lose our comprehensive NHS.

321
00:19:50,360 --> 00:19:52,960
I'm excited by innovation,
but that excitement

322
00:19:52,960 --> 00:19:55,600
is really tempered by anxiety.

323
00:19:55,600 --> 00:19:59,520
My worry about this innovation
and this rush to embrace technology

324
00:19:59,520 --> 00:20:02,360
is that we're leaving
behind the very people who stand

325
00:20:02,360 --> 00:20:04,360
to need most from
the health care service.

326
00:20:04,360 --> 00:20:07,000
Those who need most are going
to get least.

327
00:20:09,880 --> 00:20:12,880
You know, people don't have to agree
on everything all the time,

328
00:20:12,880 --> 00:20:15,120
what matters is patients
in their tens of thousands

329
00:20:15,120 --> 00:20:16,360
are agreeing with this.

330
00:20:16,360 --> 00:20:19,200
As you and I are doing
this interview, every three minutes,

331
00:20:19,200 --> 00:20:22,200
a new patient is joining Babylon.

332
00:20:22,200 --> 00:20:24,680
We have many patients
with mental health issues,

333
00:20:24,680 --> 00:20:25,920
many elderly patients.

334
00:20:25,920 --> 00:20:28,920
Our fastest-growing group
of people are the elderly.

335
00:20:33,240 --> 00:20:37,120
Fears about the impact of AI
on health care go well

336
00:20:37,120 --> 00:20:40,560
beyond suggestions that it
threatens the status quo

337
00:20:40,560 --> 00:20:42,720
and could increase inequality.

338
00:20:43,880 --> 00:20:47,600
People are asking,
how do we know it's safe,

339
00:20:47,600 --> 00:20:50,200
and is it appropriately regulated?

340
00:20:51,760 --> 00:20:55,360
From the first day of medical
school, the thing you're told is,
first, do no harm.

341
00:20:55,360 --> 00:20:57,160
And that's exactly
what patients expect.

342
00:20:57,160 --> 00:20:58,440
That's the right thing.

343
00:20:58,440 --> 00:21:01,400
And then, when you bring
that to the fast-moving world

344
00:21:01,400 --> 00:21:04,680
of technology, the move fast
and break things culture,

345
00:21:04,680 --> 00:21:06,440
clearly, there's a clash there.

346
00:21:06,440 --> 00:21:07,840
Chest X-ray. Is it really? Yes.

347
00:21:07,840 --> 00:21:12,440
And I wouldn't blame patients
and doctors and nurses for finding

348
00:21:12,440 --> 00:21:15,680
it hard to trust these
technologies at the moment

349
00:21:15,680 --> 00:21:18,920
because it's hard to find out
how they've been assessed

350
00:21:18,920 --> 00:21:21,640
as being safe, who has determined
that they are safe.

351
00:21:24,840 --> 00:21:27,880
Now, stay with me
because at this point

352
00:21:27,880 --> 00:21:30,680
I'm going to beckon
you in to the arcane world

353
00:21:30,680 --> 00:21:32,720
of health care regulation.

354
00:21:33,920 --> 00:21:38,320
Apps like Babylon's
are regulated by the MHRA -

355
00:21:38,320 --> 00:21:42,080
the Medicines and Healthcare
products Regulatory Agency.

356
00:21:42,080 --> 00:21:45,600
But what you might be surprised
to learn is that they are classified

357
00:21:45,600 --> 00:21:50,000
in the lowest possible
category of medical device

358
00:21:50,000 --> 00:21:55,040
alongside things like bandages
or Zimmer frames and spectacles.

359
00:21:56,160 --> 00:21:59,160
In this category,
it is the manufacturers themselves

360
00:21:59,160 --> 00:22:04,200
who vouch for the effectiveness
and safety of their product,

361
00:22:04,280 --> 00:22:08,240
and that means that we only
have Babylon's word for it

362
00:22:08,240 --> 00:22:10,920
that their app is safe.

363
00:22:10,920 --> 00:22:15,800
Now, there are a lot of very strict
rules about what AI symptom checkers

364
00:22:16,480 --> 00:22:19,000
are and aren't allowed to do
if they're to qualify

365
00:22:19,000 --> 00:22:22,920
for this quite quick
and easy way to launch.

366
00:22:22,920 --> 00:22:26,960
They are allowed to collect data
on symptoms and to provide

367
00:22:26,960 --> 00:22:30,960
information, but they're not
allowed to give any feedback

368
00:22:30,960 --> 00:22:35,680
that could replace a human medic's
advice or offer anything

369
00:22:35,680 --> 00:22:38,840
that could appear to be a diagnosis.

370
00:22:42,640 --> 00:22:46,240
In the case of Babylon,
whose human GPs are inspected

371
00:22:46,240 --> 00:22:49,520
and regulated just like
any other UK doctor,

372
00:22:49,520 --> 00:22:52,600
its patients could be forgiven
for thinking that,

373
00:22:52,600 --> 00:22:56,640
with their AI chatbot,
they're consulting something

374
00:22:56,640 --> 00:22:59,680
very like an online doctor.

375
00:22:59,680 --> 00:23:01,800
Is the pain in the lower
left part of your tummy

376
00:23:01,800 --> 00:23:03,840
close to the worst pain
that you've ever felt?

377
00:23:03,840 --> 00:23:08,440
The chatbot does seem to be working
towards a diagnosis.

378
00:23:08,440 --> 00:23:10,360
..Best describes the pain
in the lower left...

379
00:23:10,360 --> 00:23:14,320
The GP At Hand website explains
the symptom checker offers health

380
00:23:14,320 --> 00:23:18,160
information and fast,
accurate advice.

381
00:23:18,160 --> 00:23:21,200
But, in fact, its terms
and conditions say

382
00:23:21,200 --> 00:23:24,280
the output does not
constitute medical advice,

383
00:23:24,280 --> 00:23:26,680
diagnosis or treatment.

384
00:23:28,720 --> 00:23:31,480
This is the first time I've heard
that somebody believes

385
00:23:31,480 --> 00:23:34,480
it's confusing and, if it is,
we need to fix it and we need

386
00:23:34,480 --> 00:23:37,680
to call on the regulators to help us
to come up with the language

387
00:23:37,680 --> 00:23:40,520
that is not confusing for the users.

388
00:23:40,520 --> 00:23:44,640
Artificial intelligence is
a new challenge for the regulators,

389
00:23:44,640 --> 00:23:47,040
and they need to figure
out how to do it.

390
00:23:47,040 --> 00:23:50,440
So there is a contradiction
between what we want to do

391
00:23:50,440 --> 00:23:54,320
and what we believe people want
versus what the regulatory

392
00:23:54,320 --> 00:23:56,120
environment is ready to.

393
00:23:57,360 --> 00:24:01,000
After this interview was filmed,
Babylon changed their website.

394
00:24:05,320 --> 00:24:09,400
Confusion about the regulation
of AI health products

395
00:24:09,400 --> 00:24:11,600
is clearly a problem.

396
00:24:11,600 --> 00:24:14,160
But what about the science?

397
00:24:14,160 --> 00:24:17,360
Do such products stand
up to traditional,

398
00:24:17,360 --> 00:24:19,440
scientific scrutiny?

399
00:24:20,400 --> 00:24:24,600
These are peer-reviewed medical
journals, where professional experts

400
00:24:24,600 --> 00:24:29,240
anonymously review each other's work
and make sure that it's good

401
00:24:29,240 --> 00:24:33,440
science - robust, accurate
and significant.

402
00:24:33,440 --> 00:24:37,760
And, every year, up to 1 million
research papers are published

403
00:24:37,760 --> 00:24:42,720
in journals like this, and yet,
despite the frenzy around AI

404
00:24:44,320 --> 00:24:49,200
in health care, this is the sum
total of all publications to date

405
00:24:50,320 --> 00:24:55,080
on peer-reviewed clinical trials
that assess real time,

406
00:24:55,080 --> 00:24:59,880
real world impacts of
this technology on patients.

407
00:24:59,880 --> 00:25:02,120
That's right - one paper.

408
00:25:05,320 --> 00:25:10,280
There are a handful more where AI
and human doctors are set to work

409
00:25:10,480 --> 00:25:15,000
on the same past data,
but basically the AI health field

410
00:25:15,000 --> 00:25:19,560
is booming and yet there's been
little scientific proof

411
00:25:19,560 --> 00:25:21,880
that these products are effective.

412
00:25:23,040 --> 00:25:26,920
But this is a reflection
of how the tech industry works.

413
00:25:26,920 --> 00:25:31,360
With huge investments at stake,
companies often keep their methods

414
00:25:31,360 --> 00:25:35,680
as a closely guarded secret and,
as far as they see it,

415
00:25:35,680 --> 00:25:38,920
they can't afford to wait
for the long-winded process

416
00:25:38,920 --> 00:25:42,200
of getting a paper
reviewed and published.

417
00:25:43,600 --> 00:25:46,040
At the moment, we see
a bit of a Wild West.

418
00:25:46,040 --> 00:25:51,000
We see some companies
that are going about things in a way

419
00:25:51,000 --> 00:25:56,000
that is highly informed by the kind
of concept of evidence and clinical

420
00:25:56,200 --> 00:26:00,960
trials, but at the other end,
we have the companies that are kind

421
00:26:00,960 --> 00:26:03,680
of assuming that the problems
are much simpler than

422
00:26:03,680 --> 00:26:06,840
they often turn out to be,
who are delivering things

423
00:26:06,840 --> 00:26:09,600
and putting them out on the market
without the evidence

424
00:26:09,600 --> 00:26:13,760
to support their efficacy
or their appropriateness.

425
00:26:13,760 --> 00:26:17,040
As one commentator put it,
at the moment, we have no clear

426
00:26:17,040 --> 00:26:21,400
regulator, no clear trial structure
and no clear accountability process,

427
00:26:21,400 --> 00:26:23,520
so that doesn't really
inspire confidence.

428
00:26:25,480 --> 00:26:29,120
When it comes to Babylon's
symptom checker, it hasn't

429
00:26:29,120 --> 00:26:33,920
been independently evaluated,
nor is it required to be.

430
00:26:33,920 --> 00:26:36,120
Medical director Mobasher Butt

431
00:26:36,120 --> 00:26:39,440
explains that they do testing
another way.

432
00:26:40,480 --> 00:26:43,320
Our approach to testing
and evaluation is very different

433
00:26:43,320 --> 00:26:47,480
to traditional models of evaluation,
and it has to be.

434
00:26:47,480 --> 00:26:50,680
So, when you're working
in a very fast-paced technology

435
00:26:50,680 --> 00:26:55,400
environment, there needs
to be the ability to constantly

436
00:26:55,400 --> 00:26:57,360
evaluate the things
that we're doing.

437
00:26:57,360 --> 00:27:02,400
So, once we have released a product,
the work doesn't stop there.

438
00:27:02,480 --> 00:27:05,280
We're constantly monitoring that,
so we have a whole programme

439
00:27:05,280 --> 00:27:06,880
of post-market surveillance.

440
00:27:09,720 --> 00:27:13,160
Up until now, Babylon
have never publicly proved

441
00:27:13,160 --> 00:27:15,640
that their app works.

442
00:27:15,640 --> 00:27:19,080
But they say they believe
in transparency

443
00:27:19,080 --> 00:27:22,320
and know it's essential
to win trust.

444
00:27:22,320 --> 00:27:27,000
So, in June 2018, Ali Parsa
gathers his team to make

445
00:27:27,000 --> 00:27:28,880
a big announcement.

446
00:27:28,880 --> 00:27:32,280
We can say it's brilliant,
we can run all the tests internally

447
00:27:32,280 --> 00:27:33,920
that says it's brilliant.

448
00:27:33,920 --> 00:27:37,760
It's time that we run
these tests also publicly.

449
00:27:37,760 --> 00:27:42,640
At the end of this month,
we're going to put our AI to test.

450
00:27:42,640 --> 00:27:46,400
We're going to sit the exam
of the Royal College of GPs

451
00:27:46,400 --> 00:27:47,880
related to diagnostics.

452
00:27:47,880 --> 00:27:50,240
Of course, not everything, right?

453
00:27:50,240 --> 00:27:53,440
The second thing we're going
to do is be blind-tested

454
00:27:53,440 --> 00:27:55,040
with a set of questions.

455
00:27:55,040 --> 00:27:58,080
Those are the symptoms
that a patient will present

456
00:27:58,080 --> 00:28:01,920
itself to our machine,
and we're going to test the machine

457
00:28:01,920 --> 00:28:04,120
against those questions.

458
00:28:04,120 --> 00:28:05,600
Hopefully, we perform well.

459
00:28:05,600 --> 00:28:09,800
Otherwise, we have to fire our AI
team and get another team coming in!

460
00:28:12,080 --> 00:28:15,760
Babylon intends to publicly
demonstrate that the latest model

461
00:28:15,760 --> 00:28:19,560
of their AI chatbot
is a match for human doctors.

462
00:28:22,520 --> 00:28:25,040
If we do this, we are it.

463
00:28:28,120 --> 00:28:32,320
So, in a few weeks' time,
when they pit the chatbot's

464
00:28:32,320 --> 00:28:36,240
triage and diagnostic
skills against human GPs,

465
00:28:36,240 --> 00:28:38,560
will the AI succeed?

466
00:28:39,760 --> 00:28:43,520
And will sharing the evidence
with the world be enough to secure

467
00:28:43,520 --> 00:28:46,080
the trust they need to stay ahead?

468
00:28:52,320 --> 00:28:54,560
One British company in the race to

469
00:28:54,560 --> 00:28:58,440
transform health care
have already submitted their AI

470
00:28:58,440 --> 00:29:03,320
to a full, peer-reviewed trial by an
independent research organisation.

471
00:29:05,120 --> 00:29:08,760
Kheiron Medical aim to use
AI to revolutionise

472
00:29:08,760 --> 00:29:10,600
breast cancer diagnosis.

473
00:29:12,200 --> 00:29:15,280
Because their target
customers are hospitals,

474
00:29:15,280 --> 00:29:20,120
they've taken a cautious approach,
rigorously testing their AI

475
00:29:20,120 --> 00:29:22,840
before it's let loose on patients.

476
00:29:24,800 --> 00:29:28,280
We've been working on this for
about two years now,

477
00:29:28,280 --> 00:29:32,440
acquiring data from clinical
partners, building algorithms

478
00:29:32,440 --> 00:29:33,960
and testing them.

479
00:29:33,960 --> 00:29:37,600
We want to make sure
we get it right because,

480
00:29:37,600 --> 00:29:40,080
in the end, if our technology
is going to be in a situation

481
00:29:40,080 --> 00:29:43,280
where it's helping make
life or death decisions,

482
00:29:43,280 --> 00:29:47,520
I think it's the only sort
of ethical way to build

483
00:29:47,520 --> 00:29:49,160
this kind of technology.

484
00:29:50,920 --> 00:29:54,880
Kheiron's system that aims
to use AI to detect cancer

485
00:29:54,880 --> 00:29:59,520
in breast X-ray images called
mammograms uses the cutting edge

486
00:29:59,520 --> 00:30:02,160
technique known as deep learning.

487
00:30:03,840 --> 00:30:05,200
We say, "This is an image.

488
00:30:05,200 --> 00:30:07,640
"It has cancer in it.

489
00:30:07,640 --> 00:30:08,960
"In fact here's a million images.

490
00:30:08,960 --> 00:30:10,280
"These ones have cancer in.

491
00:30:10,280 --> 00:30:12,360
"Here's a million images
that don't have cancer.

492
00:30:12,360 --> 00:30:15,040
"You figure out
what the features are."

493
00:30:15,040 --> 00:30:19,960
With enough good image data,
deep learning AI will establish

494
00:30:19,960 --> 00:30:23,320
its own methods
for spotting cancers.

495
00:30:23,320 --> 00:30:27,320
Once you've actually trained it,
you can then test it.

496
00:30:27,320 --> 00:30:30,040
That, and data that your model
has never seen before,

497
00:30:30,040 --> 00:30:32,320
never been tested on,
never been trained on, and that's

498
00:30:32,320 --> 00:30:34,880
what are used to validate your
model.

499
00:30:36,720 --> 00:30:40,360
Mammograms are very
information-dense images.

500
00:30:40,360 --> 00:30:42,200
Millions and millions of pixels.

501
00:30:42,200 --> 00:30:45,240
And, sometimes, the abnormality
can just be a few pixels.

502
00:30:45,240 --> 00:30:49,120
Not only are you trying to find
small amounts of pixel information

503
00:30:49,120 --> 00:30:52,480
within a million-pixel image,
the proportion of women

504
00:30:52,480 --> 00:30:55,000
who actually have cancer that come
to a screening programme

505
00:30:55,000 --> 00:30:57,000
is very small. It's about 1%.

506
00:30:57,000 --> 00:30:59,960
So, it's like trying to look
for a needle within a haystack

507
00:30:59,960 --> 00:31:01,280
within a haystack.

508
00:31:03,720 --> 00:31:06,360
In Britain's breast
screening programme,

509
00:31:06,360 --> 00:31:11,280
each mammogram is usually read
by two trained experts to minimise

510
00:31:11,280 --> 00:31:13,400
the risk of missing cancers.

511
00:31:14,720 --> 00:31:18,000
If Kheiron's AI can do
some of that work,

512
00:31:18,000 --> 00:31:23,040
it will save doctors precious time,
and that could be life saving

513
00:31:23,720 --> 00:31:28,280
for the one in eight British women
diagnosed with breast cancer.

514
00:31:30,400 --> 00:31:35,080
Breast surgeon Dr Liz O'Riordan,
who advises Kheiron,

515
00:31:35,080 --> 00:31:37,360
speaks from her own experience.

516
00:31:38,520 --> 00:31:40,320
A couple of years ago,
I was diagnosed with

517
00:31:40,320 --> 00:31:41,880
breast cancer myself.

518
00:31:41,880 --> 00:31:45,960
I've seen first-hand just how awful
the full gamut of breast cancer

519
00:31:45,960 --> 00:31:47,800
treatment could be.

520
00:31:47,800 --> 00:31:50,760
If a AI and technology can reduce
the time it takes for women

521
00:31:50,760 --> 00:31:53,280
to get their results,
it means they get their biopsies

522
00:31:53,280 --> 00:31:55,120
quicker, they get their cancer
diagnosis quicker,

523
00:31:55,120 --> 00:31:57,360
they start treatment quicker.

524
00:31:57,360 --> 00:32:01,000
Kheiron's clinical trial
results prove their AI

525
00:32:01,000 --> 00:32:04,160
is outperforming humans.

526
00:32:04,160 --> 00:32:08,080
What we've managed to demonstrate
with our first trial

527
00:32:08,080 --> 00:32:12,960
is that our system is both
more sensitive and more specific

528
00:32:16,480 --> 00:32:19,680
at making that decision
of whether there's a cancer or not

529
00:32:19,680 --> 00:32:20,720
in an image.

530
00:32:22,760 --> 00:32:27,600
So, in future, rather than two human
radiologists scrutinising each

531
00:32:27,600 --> 00:32:32,480
image, one could be
paired with an AI.

532
00:32:32,480 --> 00:32:37,040
Since 97% of British radiology
departments are understaffed,

533
00:32:37,040 --> 00:32:39,200
this could be transformative.

534
00:32:41,040 --> 00:32:44,480
But, even with such
promising trial results,

535
00:32:44,480 --> 00:32:49,560
deciding to trust AI
is far from straightforward.

536
00:32:51,800 --> 00:32:54,680
to make me accept new AI technology
and it's really hard

537
00:32:54,680 --> 00:32:56,680
because it's never
been done before.

538
00:32:56,680 --> 00:32:59,200
I don't know what standards
it should meet.

539
00:32:59,200 --> 00:33:01,880
Breast cancer is based
on trials with 20,

540
00:33:01,880 --> 00:33:05,000
30 years follow-up that look at
hundreds of thousands of women,

541
00:33:05,000 --> 00:33:07,000
and you don't have the time to get
that follow-up to bring

542
00:33:07,000 --> 00:33:09,600
in new technology because it
might change in a year -

543
00:33:09,600 --> 00:33:11,680
let alone 20 years.

544
00:33:11,680 --> 00:33:13,920
I'd want to know that
it's been assessed by people

545
00:33:13,920 --> 00:33:15,960
who are independent,
who have nothing to gain,

546
00:33:15,960 --> 00:33:17,840
no financial interest.

547
00:33:17,840 --> 00:33:20,360
And, if this is to save money
to improve resources,

548
00:33:20,360 --> 00:33:23,240
is that money being ploughed back
into NHS services instead

549
00:33:23,240 --> 00:33:26,000
of just going into
the profit of the company?

550
00:33:26,000 --> 00:33:29,200
And I think it is being very sure
it is patient-driven.

551
00:33:29,200 --> 00:33:32,960
And that would make me think,
"OK, this is good."

552
00:33:32,960 --> 00:33:36,720
In Britain, many are
recommending caution,

553
00:33:36,720 --> 00:33:40,400
but in some parts of the world,
they're thinking more of

554
00:33:40,400 --> 00:33:42,200
opportunity than risk.

555
00:33:49,400 --> 00:33:54,360
This is Rwanda in Africa - one
of the world's poorest countries.

556
00:34:00,440 --> 00:34:03,600
Yet, surprisingly,
it's a global leader

557
00:34:03,600 --> 00:34:07,760
in experimenting with AI
and tech to transform

558
00:34:07,760 --> 00:34:09,600
its citizens' health care.

559
00:34:10,600 --> 00:34:15,680
We generally have a strategy to
attract proof of concept companies.

560
00:34:15,680 --> 00:34:20,160
If a company out there in the UK
or the US is trying to test

561
00:34:20,160 --> 00:34:23,920
an idea - either for the first time
and they are looking for a place to,

562
00:34:23,920 --> 00:34:26,040
you know, if you like,
a laboratory to try it out,

563
00:34:26,040 --> 00:34:27,880
we open Rwanda for them.

564
00:34:27,880 --> 00:34:29,880
That has been our strategy.

565
00:34:29,880 --> 00:34:32,320
Be bold. Try something. Experiment.

566
00:34:32,320 --> 00:34:36,920
If it doesn't work, you know,
move on and count your losses.

567
00:34:36,920 --> 00:34:40,640
This openness to being the testing
ground for new tech means

568
00:34:40,640 --> 00:34:43,680
that Rwanda has welcomed in Babylon.

569
00:34:43,680 --> 00:34:45,760
Here, they're known as Babyl.

570
00:35:07,920 --> 00:35:12,320
Rwanda's 12 million people
are served by fewer than 2,000

571
00:35:12,320 --> 00:35:16,160
doctors, but the vast
majority of adult Rwandans

572
00:35:16,160 --> 00:35:17,640
have a mobile phone.

573
00:35:19,280 --> 00:35:23,320
If they sign up to Babyl,
they can get fast triage and direct

574
00:35:23,320 --> 00:35:27,040
access to a doctor -
just like they could in Britain.

575
00:35:43,960 --> 00:35:48,880
Ibrahim Misafiri lives 40 minutes'
walk from his local health centre,

576
00:35:49,320 --> 00:35:51,480
which doesn't have a doctor.

577
00:36:11,000 --> 00:36:14,360
Because most Rwandans
don't have a smartphone,

578
00:36:14,360 --> 00:36:19,000
people like Ibrahim call Babyl's HQ,
where nurses use the same AI

579
00:36:19,000 --> 00:36:21,040
chatbot as UK users.

580
00:36:48,120 --> 00:36:51,400
Rwanda has universal
health insurance.

581
00:36:51,400 --> 00:36:55,120
And, any consultation,
whether in person or via Babyl,

582
00:36:55,120 --> 00:36:57,080
costs the same flat fee.

583
00:37:09,280 --> 00:37:13,640
It's the possibility of treating
vastly more patients with the same

584
00:37:13,640 --> 00:37:17,000
number of doctors that makes
this public health experiment

585
00:37:17,000 --> 00:37:20,680
in Rwanda so potentially
significant for the world.

586
00:37:22,160 --> 00:37:26,800
In Babyl, we employ about 16
doctors and 16 nurses.

587
00:37:26,800 --> 00:37:30,280
And if we're operating at capacity,
we can do about 2,000 consultations

588
00:37:30,280 --> 00:37:32,720
in one day.

589
00:37:32,720 --> 00:37:35,760
With the AI technology
for the triage tool,

590
00:37:35,760 --> 00:37:38,400
if that can be given
to non-clinical staff,

591
00:37:38,400 --> 00:37:40,240
are you looking at how
the numbers are expanding?

592
00:37:40,240 --> 00:37:44,520
How the number of consultations
and how we are using technology

593
00:37:44,520 --> 00:37:47,120
to stretch the limited
resources that are available

594
00:37:47,120 --> 00:37:49,760
to be able to do more in Randa.

595
00:37:52,520 --> 00:37:54,800
Pretty impressive.

596
00:37:54,800 --> 00:37:58,640
But some people have nonetheless
raised concerns that an AI system

597
00:37:58,640 --> 00:38:03,680
built and trained in the UK isn't
yet much use on common tropical

598
00:38:04,200 --> 00:38:06,240
diseases like malaria,

599
00:38:06,240 --> 00:38:09,280
although Babylon are working on it.

600
00:38:09,280 --> 00:38:13,360
AIs are only as good
as what you put into them.

601
00:38:13,360 --> 00:38:18,120
And incomplete training or biases
like that can be very problematic.

602
00:38:22,680 --> 00:38:25,800
Yet we would do well to remember
the bigger picture here.

603
00:38:25,800 --> 00:38:29,840
We are living in a world
with a desperate shortage of doctors

604
00:38:29,840 --> 00:38:32,560
but where two thirds
of the population owns

605
00:38:32,560 --> 00:38:34,280
a mobile phone.

606
00:38:34,280 --> 00:38:39,360
So, if this technology can put good,
affordable health care within reach,

607
00:38:40,160 --> 00:38:43,120
surely the impetus is
to continue working

608
00:38:43,120 --> 00:38:48,160
to make AI safer, more accurate,
and more reliable.

609
00:38:54,400 --> 00:38:58,640
Back in London, the push to improve
Babylon's AI continues

610
00:38:58,640 --> 00:39:00,760
at breakneck speed.

611
00:39:00,760 --> 00:39:03,920
It's not long before the big event
where its performance

612
00:39:03,920 --> 00:39:07,320
will be compared to human doctors.

613
00:39:07,320 --> 00:39:11,160
Thinking about the event,
is a mixture of kind of

614
00:39:11,160 --> 00:39:15,320
like extreme nervousness
and also excitement.

615
00:39:15,320 --> 00:39:17,400
We want to show people
that we're doing well,

616
00:39:17,400 --> 00:39:20,360
so, there are lots of new ideas
rolling, to try and get

617
00:39:20,360 --> 00:39:23,640
to where we need to be for that.

618
00:39:23,640 --> 00:39:26,880
Babylon are trying
to advance their app,

619
00:39:26,880 --> 00:39:30,640
going beyond offering triage
advice to giving out

620
00:39:30,640 --> 00:39:32,960
diagnostic information, too.

621
00:39:37,680 --> 00:39:42,480
This has always been available
to Babylon's GPs, but the aim

622
00:39:42,480 --> 00:39:46,320
is to share it more
widely with patients.

623
00:39:46,320 --> 00:39:49,880
Medicine is fundamentally
an uncertain discipline,

624
00:39:49,880 --> 00:39:53,760
so, if a patient comes to a doctor
and tells the doctor

625
00:39:53,760 --> 00:39:57,520
about their symptoms,
often the doctor will have a variety

626
00:39:57,520 --> 00:40:00,000
of different conditions
that they may be thinking about,

627
00:40:00,000 --> 00:40:02,640
so they are uncertain about
what the underlying condition is.

628
00:40:02,640 --> 00:40:05,600
So, we need to be able to build
a system which is able to update

629
00:40:05,600 --> 00:40:08,320
that belief about what
the underlying condition is,

630
00:40:08,320 --> 00:40:10,520
based on new information.

631
00:40:10,520 --> 00:40:15,440
The new diagnostic AI system needs
to excel at calculating

632
00:40:15,440 --> 00:40:17,640
probabilities or likelihoods.

633
00:40:19,080 --> 00:40:22,920
It works by connecting
three things - symptoms,

634
00:40:22,920 --> 00:40:25,480
diseases and risk factors.

635
00:40:26,600 --> 00:40:29,840
A symptom like knee
pain could be caused

636
00:40:29,840 --> 00:40:31,960
by a disease like arthritis.

637
00:40:33,000 --> 00:40:37,960
How likely this is depends
on the risk factors like age.

638
00:40:38,120 --> 00:40:40,360
Each likelihood can be scored.

639
00:40:41,840 --> 00:40:45,480
And, as the chatbot learns
more about the patient,

640
00:40:45,480 --> 00:40:48,880
the scores may change.

641
00:40:48,880 --> 00:40:53,880
For example, a recent fall
could suggest an injury

642
00:40:54,440 --> 00:40:59,440
is causing the pain,
making arthritis a less likely

643
00:40:59,880 --> 00:41:00,880
diagnosis.

644
00:41:03,360 --> 00:41:07,200
With the new AI system,
the team can see exactly

645
00:41:07,200 --> 00:41:10,080
how it comes up with each diagnosis.

646
00:41:10,080 --> 00:41:12,320
Around the same magnitude, then...

647
00:41:12,320 --> 00:41:17,360
In that sense, they think it's step
ahead of human doctors.

648
00:41:19,440 --> 00:41:23,680
It's transparent and it's fully
accountable, so we can understand

649
00:41:23,680 --> 00:41:26,120
precisely why we've
given a diagnosis.

650
00:41:26,120 --> 00:41:28,160
That's not something humans can do.

651
00:41:28,160 --> 00:41:32,640
Humans, you know,
probably have a similar

652
00:41:32,640 --> 00:41:35,640
decision-making process
in their minds, but it's actually

653
00:41:35,640 --> 00:41:36,880
never written down.

654
00:41:36,880 --> 00:41:40,320
The fact is that here
everything is.

655
00:41:40,320 --> 00:41:42,320
There's a trail
about how a particular

656
00:41:42,320 --> 00:41:44,200
diagnosis has been arrived at.

657
00:41:44,200 --> 00:41:47,840
And we can revisit
that trail at any point.

658
00:41:47,840 --> 00:41:52,240
Babylon use this transparency
to try to improve their AI

659
00:41:52,240 --> 00:41:55,640
through repeated rounds of testing.

660
00:41:55,640 --> 00:41:57,800
So, I'm a 65-year-old man.

661
00:41:57,800 --> 00:42:00,640
OK. And how can I help you this
morning? So...

662
00:42:00,640 --> 00:42:04,280
Here, two Babylon medics
are role-playing a typical GP

663
00:42:04,280 --> 00:42:05,280
consultation.

664
00:42:06,320 --> 00:42:09,960
The pretend patient has been given
a secret set of symptoms,

665
00:42:09,960 --> 00:42:11,400
known as a vignette.

666
00:42:12,960 --> 00:42:17,960
So, Doctor, I've a really bad cough
I've had for a couple of days.

667
00:42:18,080 --> 00:42:19,960
OK. A couple of days. OK.

668
00:42:19,960 --> 00:42:22,560
When you're coughing, are you
bringing up any phlegm at all?

669
00:42:22,560 --> 00:42:24,400
Yes, pretty nasty stuff.

670
00:42:25,560 --> 00:42:29,240
After asking all the questions
he needs to, the doctor reports

671
00:42:29,240 --> 00:42:31,360
his most likely diagnoses.

672
00:42:32,720 --> 00:42:34,560
My differentials
included bronchitis,

673
00:42:34,560 --> 00:42:37,000
as well as more general influenza.

674
00:42:38,440 --> 00:42:41,680
The pretend patient then enters
exactly the same symptoms

675
00:42:41,680 --> 00:42:46,640
into the chatbot to see what the AI
thinks is wrong with him.

676
00:42:46,960 --> 00:42:51,320
What it's come out with is
bronchitis and pneumonia.

677
00:42:51,320 --> 00:42:56,000
This time, the human doctor
and the AI largely agree,

678
00:42:56,000 --> 00:42:58,120
but not always.

679
00:42:58,120 --> 00:43:00,800
This is case vignette number 10.

680
00:43:00,800 --> 00:43:03,000
So, all of a sudden,
I've just had this really,

681
00:43:03,000 --> 00:43:05,640
just like difficulty breathing.

682
00:43:05,640 --> 00:43:07,080
When did this start?

683
00:43:07,080 --> 00:43:08,840
About a half hour ago.

684
00:43:08,840 --> 00:43:11,320
It came on quite suddenly
did it, or more gradual?

685
00:43:11,320 --> 00:43:14,760
No, it just came on really sudden.
OK. And...

686
00:43:14,760 --> 00:43:19,080
Taking a thorough history is one
of the key ways a human GP

687
00:43:19,080 --> 00:43:21,480
reaches a diagnosis.

688
00:43:21,480 --> 00:43:23,080
Any recent operation?

689
00:43:23,080 --> 00:43:24,720
Any long haul flights recently?

690
00:43:24,720 --> 00:43:26,960
Um, I've had my hip done.

691
00:43:26,960 --> 00:43:28,160
OK. When was that done?

692
00:43:28,160 --> 00:43:29,520
A couple of days ago.

693
00:43:29,520 --> 00:43:31,760
A couple of days ago? OK.
Have you noticed any

694
00:43:31,760 --> 00:43:34,920
swelling of your legs
or your calves at all?

695
00:43:34,920 --> 00:43:37,200
Erm, I think, yeah,
one of them is a little bit,

696
00:43:37,200 --> 00:43:38,720
a little bit swollen.

697
00:43:40,040 --> 00:43:43,960
Having asked all the questions
he needs to, the human concludes

698
00:43:43,960 --> 00:43:47,920
that the patient most likely
has a pulmonary embolism,

699
00:43:47,920 --> 00:43:52,800
a blood clot in the lung, which is
a life-threatening condition.

700
00:43:52,800 --> 00:43:57,240
But when it is time to enter
the same symptoms into the chatbot,

701
00:43:57,240 --> 00:43:59,440
it has other ideas.

702
00:43:59,440 --> 00:44:03,760
So, with this one,
it's come up with costochondritis.

703
00:44:03,760 --> 00:44:08,200
The AI has missed the most serious
and most probable condition,

704
00:44:08,200 --> 00:44:10,240
given the patient's history.

705
00:44:11,600 --> 00:44:15,960
Though the chatbot is currently
only licensed to provide information

706
00:44:15,960 --> 00:44:20,000
to patients, and is not
to be relied on as a diagnosis,

707
00:44:20,000 --> 00:44:22,640
it seems an unnerving mistake.

708
00:44:24,880 --> 00:44:27,040
This is the whole process
by which science works.

709
00:44:27,040 --> 00:44:31,400
You test new data and then you again
try and validate, and so

710
00:44:31,400 --> 00:44:34,840
this is the process by which all
of the teams work together to try

711
00:44:34,840 --> 00:44:39,400
and refine the process,
to try and bump up that accuracy.

712
00:44:39,400 --> 00:44:42,720
But what does Ali Parsa
think of his AI missing

713
00:44:42,720 --> 00:44:44,840
a potentially fatal condition?

714
00:44:46,480 --> 00:44:51,480
Look, we have extraordinarily
unrealistic expectations,

715
00:44:52,280 --> 00:44:56,480
in terms of the accuracy,
in terms of infallibility

716
00:44:56,480 --> 00:44:58,200
of our machines.

717
00:44:58,200 --> 00:45:00,640
And that is just silly.

718
00:45:00,640 --> 00:45:05,640
For any mistakes our machine makes
today, I can name you a hundredfold

719
00:45:05,920 --> 00:45:08,920
the number of mistakes
that will be made by human doctors

720
00:45:08,920 --> 00:45:11,760
of the same order of magnitude.

721
00:45:11,760 --> 00:45:13,640
We have to be realistic.

722
00:45:13,640 --> 00:45:16,640
What we are saying is
that when you get a diagnosis

723
00:45:16,640 --> 00:45:20,760
from a machine, you have now
narrowed the field for the doctor.

724
00:45:20,760 --> 00:45:23,600
What we are not saying
is go and entirely,

725
00:45:23,600 --> 00:45:28,000
completely rely on this diagnostic
and don't talk to a doctor.

726
00:45:31,440 --> 00:45:35,800
There is a tenacious band of Babylon
critics who are waging a noisy

727
00:45:35,800 --> 00:45:39,440
Twitter war, exposing the AI
chatbot's mistakes,

728
00:45:39,440 --> 00:45:44,120
and these range from the very
serious to the somewhat ridiculous.

729
00:45:44,120 --> 00:45:48,360
For instance, one user told it,
"I have a swollen elbow,"

730
00:45:48,360 --> 00:45:52,160
which the chatbot eventually
misunderstood as "red skin

731
00:45:52,160 --> 00:45:54,200
"around the genitals."

732
00:45:54,200 --> 00:45:56,640
Cue a whole range of jokes
about how it doesn't know its arse

733
00:45:56,640 --> 00:45:58,520
from its elbow.

734
00:45:58,520 --> 00:46:02,360
The thing is, for the AI to improve,
it needs to gather data

735
00:46:02,360 --> 00:46:04,600
from lots of use.

736
00:46:04,600 --> 00:46:07,600
But plenty of people find the idea
of it learning on the job pretty

737
00:46:07,600 --> 00:46:12,320
troubling, especially when computers
are generally assumed

738
00:46:12,320 --> 00:46:14,720
to be somehow infallible.

739
00:46:16,400 --> 00:46:21,280
The future of AI-powered health care
may depend on this issue

740
00:46:21,280 --> 00:46:23,280
of how far to trust it.

741
00:46:26,160 --> 00:46:29,800
With just days to go to the big
event, which will reveal

742
00:46:29,800 --> 00:46:33,920
to the world how Babylon's AI
measures up to human doctors,

743
00:46:33,920 --> 00:46:38,960
the testing of human
versus machine intensifies.

744
00:46:39,960 --> 00:46:42,120
Feeling pretty apprehensive
about it, I think,

745
00:46:42,120 --> 00:46:44,440
not just me but the team.

746
00:46:44,440 --> 00:46:46,080
There's a lot to do.

747
00:46:46,080 --> 00:46:49,880
With every test, the team
helps the app to improve.

748
00:46:51,320 --> 00:46:53,560
There aren't many other companies
in this domain

749
00:46:53,560 --> 00:46:54,880
that are doing this.

750
00:46:54,880 --> 00:46:57,200
And somebody has to be
the first, so...

751
00:46:57,200 --> 00:46:59,240
..fingers crossed.

752
00:46:59,240 --> 00:47:01,640
I mean, I wouldn't trust
claims without evidence,

753
00:47:01,640 --> 00:47:04,080
so we kind of have to make...

754
00:47:04,080 --> 00:47:05,320
..evidence our claims.

755
00:47:09,000 --> 00:47:12,920
Finally, it's time
for Babylon's big test,

756
00:47:12,920 --> 00:47:17,320
pitching the AI against human
doctors, as before,

757
00:47:17,320 --> 00:47:19,560
but now under exam conditions.

758
00:47:21,200 --> 00:47:22,920
Could you give me your age
and gender, please?

759
00:47:22,920 --> 00:47:25,240
I'm male, I'm 21 years old.
Mmm-hmm.

760
00:47:25,240 --> 00:47:27,960
I'm feeling really short of breath.
Mmm-hmm.

761
00:47:27,960 --> 00:47:32,560
Testing takes place behind closed
doors at Babylon HQ.

762
00:47:32,560 --> 00:47:37,240
It doesn't involve real patients
and it hasn't been designed and run

763
00:47:37,240 --> 00:47:40,680
by an independent
research organisation.

764
00:47:40,680 --> 00:47:43,920
So prior to swimming earlier
today, how were you feeling?

765
00:47:43,920 --> 00:47:48,520
But the team haven't chosen
the questions or seen them

766
00:47:48,520 --> 00:47:52,480
in advance and won't be judging
the answers themselves either.

767
00:47:55,920 --> 00:48:00,200
Babylon's big test starts
with respected independent

768
00:48:00,200 --> 00:48:05,240
collaborators supplying 100 sets
of patient symptoms that a GP

769
00:48:05,600 --> 00:48:08,160
might typically encounter.

770
00:48:08,160 --> 00:48:12,360
A pretend patient takes each one,
presents it to up to seven

771
00:48:12,360 --> 00:48:17,440
independent human GPs
and also to Babylon's AI,

772
00:48:17,640 --> 00:48:19,000
via the chatbot.

773
00:48:20,080 --> 00:48:24,320
Both human doctors and AI must
respond to each case

774
00:48:24,320 --> 00:48:26,160
with triage advice...

775
00:48:27,280 --> 00:48:29,880
..and their most likely diagnoses.

776
00:48:32,480 --> 00:48:37,320
An independent judge will mark
the anonymised answers to see

777
00:48:37,320 --> 00:48:40,880
who scores highest for
safety and accuracy,

778
00:48:40,880 --> 00:48:43,960
humans or machine?

779
00:48:43,960 --> 00:48:49,000
And the AI also has a go at some
Royal College of GP exam

780
00:48:49,160 --> 00:48:51,520
questions on diagnosis.

781
00:48:58,280 --> 00:49:01,920
The Royal College of Physicians,
one of the world's most

782
00:49:01,920 --> 00:49:05,400
respected medical institutions.

783
00:49:05,400 --> 00:49:09,840
So, a bold venue choice for Babylon
to reveal their results

784
00:49:09,840 --> 00:49:10,880
to the world.

785
00:49:15,560 --> 00:49:20,200
Two years of development,
tens of millions of pounds

786
00:49:20,200 --> 00:49:25,120
of investment and a moment
of truth for Babylon's AI.

787
00:49:29,280 --> 00:49:32,240
The question is, how accurate is it?

788
00:49:32,240 --> 00:49:37,280
Can it ever, ever be as accurate
as a human doctor in diagnosis?

789
00:49:38,920 --> 00:49:42,360
Before some of Britain's
most senior medics,

790
00:49:42,360 --> 00:49:46,800
first up is the Royal College
of GPs' exam result.

791
00:49:46,800 --> 00:49:48,760
So how did Babylon's AI do?

792
00:49:49,880 --> 00:49:53,400
In the relevant tests,
the average pass mark for human

793
00:49:53,400 --> 00:49:54,480
doctors is 72%.

794
00:49:57,400 --> 00:50:02,480
Babylon's AI achieved 81%.

795
00:50:06,840 --> 00:50:10,160
But this really just is the start.

796
00:50:10,160 --> 00:50:13,640
Now, Babylon's human
versus machine test.

797
00:50:15,680 --> 00:50:20,080
How good were the seven
independent GPs at diagnosis?

798
00:50:21,240 --> 00:50:24,840
So some did OK, 64% -
not, not that great.

799
00:50:24,840 --> 00:50:27,440
But some did really,
really well - so 94%.

800
00:50:27,440 --> 00:50:31,120
But if you take an average
of this, it's around 80%.

801
00:50:31,120 --> 00:50:36,160
So in Babylon's 100 patient tests,
the human doctors on average managed

802
00:50:37,400 --> 00:50:42,120
to give an accurate diagnosis
four out of five times.

803
00:50:42,120 --> 00:50:43,680
And how did our AI do?

804
00:50:45,720 --> 00:50:50,640
So, exactly the same as the doctor
average, 80%.

805
00:50:51,880 --> 00:50:53,880
And what of safety?

806
00:50:53,880 --> 00:50:57,360
How safe were the AI's
triage recommendations?

807
00:50:59,320 --> 00:51:04,040
Human doctors were able to give
a safe triage outcome 93.1%

808
00:51:04,040 --> 00:51:05,040
of the time.

809
00:51:06,440 --> 00:51:09,760
In terms of the AI,
we were able to give a safe triage

810
00:51:09,760 --> 00:51:12,120
outcome 97% of the time.

811
00:51:21,280 --> 00:51:24,720
As the event ends,
Babylon release their research

812
00:51:24,720 --> 00:51:27,360
and results for the scrutiny of all.

813
00:51:29,000 --> 00:51:33,960
So far as Ali Parsa is concerned,
Babylon have now verified that AI

814
00:51:34,240 --> 00:51:37,120
matches human GPs at diagnosis.

815
00:51:38,760 --> 00:51:41,160
We absolutely now have proof.

816
00:51:41,160 --> 00:51:43,960
How would that be a claim?

817
00:51:43,960 --> 00:51:47,920
Entirely independent people,
from the United States

818
00:51:47,920 --> 00:51:50,360
all the way to the Royal
College of Physicians,

819
00:51:50,360 --> 00:51:54,400
created vignettes
that the machine sat and passed.

820
00:51:54,400 --> 00:51:58,640
The results were
independently judged by...

821
00:52:00,080 --> 00:52:02,440
..a doctor at Harvard.

822
00:52:02,440 --> 00:52:04,160
And we published the results.

823
00:52:04,160 --> 00:52:05,960
It is all in our paper.

824
00:52:05,960 --> 00:52:10,040
And, look - if we ran these tests
again and the result

825
00:52:10,040 --> 00:52:12,880
is a little bit
different, who cares?

826
00:52:12,880 --> 00:52:16,720
What really matters is that we're
getting better and better.

827
00:52:16,720 --> 00:52:18,560
I mean, that is mind-boggling,

828
00:52:18,560 --> 00:52:20,960
the speed at which a machine
can learn.

829
00:52:20,960 --> 00:52:25,720
They can never forget,
they can never have all the other

830
00:52:25,720 --> 00:52:29,560
problems that we have as humans.

831
00:52:29,560 --> 00:52:32,360
It's an absolute fact,
any way they can put

832
00:52:32,360 --> 00:52:34,000
it to test now, right?

833
00:52:36,040 --> 00:52:40,120
But some scientists
question Babylon's methods,

834
00:52:40,120 --> 00:52:45,120
saying the study was too small
for meaningful statistical analysis,

835
00:52:45,120 --> 00:52:50,040
as well as not being fully
independent or peer-reviewed.

836
00:52:50,480 --> 00:52:53,120
So what does the medical
establishment make of

837
00:52:53,120 --> 00:52:55,320
what they've seen?

838
00:52:55,320 --> 00:52:58,160
What they've done is they've done
it in a lab environment.

839
00:52:58,160 --> 00:53:02,040
They've done it in vignettes,
without real patients.

840
00:53:02,040 --> 00:53:07,080
I want to see that algorithm compete
with a doctor over many,

841
00:53:08,120 --> 00:53:13,040
many cases, and dealing with Enid,
who's 85, who's got multiple

842
00:53:13,040 --> 00:53:15,440
problems, hard of hearing.

843
00:53:15,440 --> 00:53:18,000
She's never going to use the phone.

844
00:53:18,000 --> 00:53:23,000
So I remain excited at the promise
and I remain cynical at the moment.

845
00:53:25,200 --> 00:53:28,320
I think GPs will initially feel
quite threatened by this,

846
00:53:28,320 --> 00:53:32,920
if the choice is a machine or a GP,
but we all know it's not.

847
00:53:32,920 --> 00:53:36,160
The choice is, how do we improve
what GPs can do already

848
00:53:36,160 --> 00:53:39,200
and which takes them a lot of time
and often a lot of frustration

849
00:53:39,200 --> 00:53:41,880
and a great deal of stress,
which worries me enormously

850
00:53:41,880 --> 00:53:45,080
about general
practitioners in England.

851
00:53:45,080 --> 00:53:50,080
The strongest criticism comes
from the Royal College of GPs,

852
00:53:50,080 --> 00:53:55,120
whose diagnosis exam Babylon say
their AI effectively passed.

853
00:53:56,320 --> 00:53:57,920
Babylon don't have our exam.

854
00:53:57,920 --> 00:54:01,160
Babylon used sample
old questions from our website,

855
00:54:01,160 --> 00:54:03,360
which they used,
as far as we understand.

856
00:54:03,360 --> 00:54:06,440
Our exam is highly confidential.

857
00:54:06,440 --> 00:54:09,160
I had a phone call the night
before the presentation to say

858
00:54:09,160 --> 00:54:11,680
that they were going to be making
these claims and I did ask

859
00:54:11,680 --> 00:54:14,360
lots of questions. I asked about
independent evaluation.

860
00:54:14,360 --> 00:54:15,800
I asked to see the data.

861
00:54:15,800 --> 00:54:17,600
I asked to see the methodology.

862
00:54:17,600 --> 00:54:20,200
Now, I didn't get to see those
things, and for a very long time.

863
00:54:20,200 --> 00:54:23,320
However, it's interesting to see.

864
00:54:23,320 --> 00:54:26,480
It's innovative of them to try
and evaluate it and I'm glad to see

865
00:54:26,480 --> 00:54:28,000
them trying to evaluate that.

866
00:54:28,000 --> 00:54:30,440
It's a good attempt
in the right direction.

867
00:54:30,440 --> 00:54:32,240
But we have a very long way to go.

868
00:54:32,240 --> 00:54:35,280
What they have not done is published
in any peer-reviewed journal.

869
00:54:35,280 --> 00:54:39,040
What they have not done is follow
any robust scientific methodology.

870
00:54:39,040 --> 00:54:42,080
And what they have not done is allow
others in to independently

871
00:54:42,080 --> 00:54:44,640
evaluate their research to date.

872
00:54:44,640 --> 00:54:46,680
All those things are possible
and we look forward

873
00:54:46,680 --> 00:54:48,480
to them happening.

874
00:54:48,480 --> 00:54:49,800
We disagree with that.

875
00:54:49,800 --> 00:54:53,440
We think there is a very robust
scientific approach and our

876
00:54:53,440 --> 00:54:56,240
scientists' reputation
and name is on it.

877
00:54:56,240 --> 00:54:59,680
As any scientist knows,
the peer review system was invented

878
00:54:59,680 --> 00:55:01,480
in the 18th century.

879
00:55:01,480 --> 00:55:03,080
It was...

880
00:55:03,080 --> 00:55:06,760
..widely became common in the 19th
and early parts of the 20th century,

881
00:55:06,760 --> 00:55:09,600
but it has a speed and at that time,
science was progressing

882
00:55:09,600 --> 00:55:10,920
at a certain speed.

883
00:55:10,920 --> 00:55:15,480
So it takes normally 12-18 months
from the time you do research

884
00:55:15,480 --> 00:55:17,760
for a peer-review
paper to be published.

885
00:55:17,760 --> 00:55:21,320
That, in technology,
is a very long time.

886
00:55:21,320 --> 00:55:25,280
Of course, we have to be in a hurry
to bring accessible,

887
00:55:25,280 --> 00:55:28,080
affordable health care for
everybody on earth.

888
00:55:28,080 --> 00:55:30,760
It's not an intellectual exercise.

889
00:55:30,760 --> 00:55:31,920
It's a mission.

890
00:55:36,000 --> 00:55:39,040
After the event, it's not
just Ali Parsa answering

891
00:55:39,040 --> 00:55:40,840
questions about Babylon.

892
00:55:40,840 --> 00:55:45,560
On his first day at the despatch
box, the incoming Health Secretary

893
00:55:45,560 --> 00:55:47,880
is in the firing line, too.

894
00:55:47,880 --> 00:55:51,280
Is the Secretary of State familiar
with the GP At Hand online service,

895
00:55:51,280 --> 00:55:54,520
which has poached thousands
of profitable patients from GPs

896
00:55:54,520 --> 00:55:58,920
all over London, to the alarm
of the BMA and GPs generally?

897
00:55:58,920 --> 00:56:01,600
This is creating a two tier
service for GPs.

898
00:56:01,600 --> 00:56:04,240
Will the Secretary of
State investigate it?

899
00:56:04,240 --> 00:56:07,560
Erm, yes, I'm acutely aware of this,
the question that he raises,

900
00:56:07,560 --> 00:56:12,000
not least because I'm a user
of the Babylon service myself.

901
00:56:12,000 --> 00:56:13,680
They are my GP.

902
00:56:13,680 --> 00:56:17,240
Despite Matt Hancock's
personal endorsement,

903
00:56:17,240 --> 00:56:19,880
NHS England are now investigating.

904
00:56:21,120 --> 00:56:24,520
There is no greater enthusiast
for technology than me,

905
00:56:24,520 --> 00:56:27,240
Mr Speaker, as you well know.

906
00:56:27,240 --> 00:56:29,920
But the thing about new technology
is that sometimes

907
00:56:29,920 --> 00:56:32,440
the rules need to be updated
to take into account

908
00:56:32,440 --> 00:56:33,920
the changes in technology.

909
00:56:33,920 --> 00:56:35,720
So they've been properly
evaluated...

910
00:56:35,720 --> 00:56:39,880
The regulations governing AI health
products are being reviewed

911
00:56:39,880 --> 00:56:42,800
to ensure they are
safe and effective.

912
00:56:42,800 --> 00:56:44,840
The answer, where there
are challenges such as the ones

913
00:56:44,840 --> 00:56:47,920
she raises, is not
to reject the technology.

914
00:56:47,920 --> 00:56:51,160
The opposite, it's to keep improving
the technology so it gets better

915
00:56:51,160 --> 00:56:54,200
and better and make sure
the rules keep up to pace.

916
00:56:54,200 --> 00:56:59,240
The NHS has appointed an independent
evaluation of GP At Hand,

917
00:56:59,520 --> 00:57:02,760
and its impact on
the health care system.

918
00:57:02,760 --> 00:57:06,000
For now, it has decided not
to approve Babylon's

919
00:57:06,000 --> 00:57:08,440
expansion outside London.

920
00:57:08,440 --> 00:57:11,960
Yes, it's important to make
sure that it works well

921
00:57:11,960 --> 00:57:15,000
and that the rules are right,
but if we turn our backs

922
00:57:15,000 --> 00:57:16,960
on new technology,
we're turning our backs

923
00:57:16,960 --> 00:57:18,080
on better care.

924
00:57:24,520 --> 00:57:29,440
Revolutions are famously hard
to judge without the benefit

925
00:57:29,440 --> 00:57:31,840
of a lot of hindsight.

926
00:57:31,840 --> 00:57:34,000
So working out what to make
of the one we're living

927
00:57:34,000 --> 00:57:36,880
through right now is not easy.

928
00:57:38,080 --> 00:57:41,200
For me, there is no question
that we could all stand to benefit

929
00:57:41,200 --> 00:57:46,200
enormously from this revolution
in AI health care.

930
00:57:46,640 --> 00:57:49,480
In fact, after a while,
it might become immoral not to use

931
00:57:49,480 --> 00:57:53,520
AI, if it can outperform humans
in so many different tasks.

932
00:57:53,520 --> 00:57:56,600
But at the same time,
we might still feel,

933
00:57:56,600 --> 00:57:59,240
understandably, anxious
about whether or not

934
00:57:59,240 --> 00:58:01,040
we can trust it.

935
00:58:01,040 --> 00:58:04,280
Because this new technology,
these algorithms, they're only

936
00:58:04,280 --> 00:58:08,280
as good as the humans
who are involved, the scientists,

937
00:58:08,280 --> 00:58:13,200
the inventors, the entrepreneurs,
the politicians and the regulators.

938
00:58:13,200 --> 00:58:17,880
And, in this age of human
and machine, it's only right

939
00:58:17,880 --> 00:58:19,920
that we should keep an eye on both.

940
00:58:21,920 --> 00:58:24,400
Businesses, technology
businesses in the UK,

941
00:58:24,400 --> 00:58:29,240
are creating an environment which is
safe and secure for investment...

942
00:58:29,240 --> 00:58:31,680
Secretary of State, Matt Hancock.

943
00:58:35,080 --> 00:58:37,600
Thanks, Ali, and it is great

944
00:58:37,600 --> 00:58:40,320
to be here to support GP At Hand.

