COURTNEY B. VANCE: 1939.
A chemist at a Midwestern paint company
makes a startling discovery,
one that could improve the health of millions of people.
The company wants him to stick to making paint,
but this man has always gone his own way.
He was the grandson of Alabama slaves,
yet he went on to become one of America's great scientists.
HELEN PRINTY: He had to fight to overcome the odds
of being a Black man in America.
JOHN KENLY SMITH: The chemical world was a club,
and outsiders were not really all that welcome.
PETER WALTON: We lived, for the most part,
in a highly stressed,
very competitive environment.
VANCE: Outside the laboratory,
he faced challenges of a different kind.
PERCY JULIAN (dramatized): Once the violence began...
(distant explosion)
Anna and I felt we had no choice but to stay.
PERCY JULIAN, JR.: My dad was angry when he came home,
and clearly ready to fight.
Allow me...
JULIAN, SR.: For more than a century,
we have watched the denial of elemental liberty
to millions of Black people in our southland.
♪
VANCE: He found freedom in the laboratory.
His science helped unlock the secret chemistry of plants,
a discovery that would help relieve
one of the most crippling human diseases...
and plunge him into one of the fiercest battles
in the history of science.
GREGORY PETSKO: This is one of the towering figures of chemistry
in the 20th century
and one of the great African-American scientists of all time.
VANCE: A brilliant chemist...
JULIAN, SR.: Trust me!
VANCE: ...a volatile personality...I will prove him wrong!
VANCE:A man whose devotion to science would not be denied.
WILLIE PEARSON: This man was
Exhibit A of determination
and never giving up.
MAN: Please state your full name for the record.
My name is Percy Julian.
♪
(birds chirping, insects buzzing)
♪
VANCE: Every spring in Oak Park, Illinois,
people from all over the village would go out of their way
to see the explosion of color at the home on East Avenue.
JULIAN, JR.:The tulips just went on forever.
My dad, he'd be out there in his black beret,
and my sense was that he had this love affair
with, with... with growing things.
VANCE: What many passersby
didn't realize was that the tulip grower
was also one of America's great scientists.
JULIAN (recorded): Ladies and gentlemen, essentially,
I'm going to talk with you about three plants,
three marvelous plants...
JULIAN (dramatized): ...three marvelous plants
that make the words of the psalmist come true
and ring true again.
"Consider the lilies of the field: they toil not,
"neither do they spin, and yet Solomon in all his glory
was never arrayed like one of these."
VANCE: It was not simply the beauty of plants
that captivated Percy Julian,
but their ability to produce
an endless variety of powerful chemicals.
In the 1930s, Julian set out to tap what he called
the "natural laboratories" of plants
to make a new class of drugs
that would help millions of people.
Spoiled? What do you mean, spoiled?
VANCE: Julian fought through extraordinary obstacles
to make a place for himself in a profession
and a country divided by race.
JAMES ANDERSON: The message from white society
is very clear:
it is not your achievement or your merit
or your accomplishments that matter,
it's the color of your skin, andbecause of that you're rejected.
PETSKO: Yet over and over again, he doesn't let this stop him.
He presses on, sure that his vision of where he wants to go
and how he wants to get there is right.
Stop!
JAMES SHOFFNER: After Percy Julian,
nobody could say anymorethat Blacks couldn't do science,
because he was atthe very top of his profession.
The story I will tell you tonight
is a story of wonder and amazement,
almost a story of miracles.
It is a story of laughter and tears.
It is a story of human beings,
therefore, a story of meanness, of stupidity,
of kindness and nobility.
One beautiful morning,
when I was 12 years old, I went berry-picking
on my grandfather's farm in Alabama.
I shall never forget how beautiful life seemed
to me that morning...
...under the spell of an Alabama forest.
♪
But in the midst of that beauty...
...I came across a Negro body
hanging from a tree.
He had been lynched a few hours earlier.
He didn't look like a criminal;
he just looked like a scared boy.
♪
On the way back, I encountered
and killed a rattlesnake.
For years afterward, every time I saw a white man,
I involuntarily saw the contours
of a rattlesnake head on his face.
Many years later, a reporter asked me
what were my greatest nightmaresfrom my childhood in the South.
I told him, "White folks and rattlesnakes."
VANCE: Percy Lavon Julian was born in Montgomery, Alabama, in 1899,
at a time when Southerners lived under a system
of forced segregation called Jim Crow.
ANDERSON:I think the greatest consequence of Jim Crow is fear.
You knew if you said the wrongthing or went in the wrong door
or drank out of the wrong water fountain...
that any of those things could lead to your death.
VANCE: To shelter his children from this oppressive atmosphere,
Julian's father turned to the world of ideas.
JULIAN: Every penny my father could
scrape together went into building
a wonderful library for his children,
for the public library was closed to us.
My father created, in my imagination,
brave new worlds to conquer.
VANCE: As a young man, James Julian had been a schoolteacher.
His wife Elizabeth was a teacher, too.
They believed education offered the path
to a better life for Black people.
I'm going to show yousomething.
VANCE: Denied his own chance to go to college,
James made it his mission to send his children instead,
but it would not be easy.
In Montgomery, and across most of the South,
public schools for Black children simply stopped
after the eighth grade.
ANDERSON:The message from white society, to Black students,
was that you should have just enough education
to be good field hands and good laborers,
cooks and maids and so forth.
VANCE: With no high school to attend,Percy Julian completed two years
at the local teacher training school for Negroes.
In 1916, with barely a tenth-grade education,
Percy Julian became the first member of his family
to live out his father's dream.
JULIAN: During the hectic week of preparations,
my father had taken me aside for a long talk.
"This is the greatest moment of your life," he told me.
"But it is also a great responsibility,
"for you are now beginning to create a family,
a family of educated people."
There they were,
three generations of hope
and prayer,
waving to a fourth generation that was going off to college.
And why?
Because they had the simple faith
that the last great hope of the Earth
is education for all the people.
♪
VANCE: Julian's destination was DePauw University,
a small liberal arts college in Greencastle, Indiana.
DePauw had accepted a few Black students since the Civil War,
but expected them to know their place.
ANDERSON: A Black student entering a white university--
if they didn't know before they arrived,
they found out, pretty quickly,
that they were not welcome in the university
or in the community.
Let's go over this way...
VANCE: Instead of being assigned to a dorm
like his white classmates,
Julian was shown to an off-campus room
with a slop jar for a toilet.
I soon got up enough courage
to ask Mrs. Townsend what time we would have dinner,
but she tersely informed me
that she was not expected to give me my meals.
VANCE: Julian wandered the streets of Greencastle
for a day and a half before finding a diner
that would serve a Negro.
He would continue to take his meals off campus
until he learned of an opening at the Sigma Chi fraternity.
In exchange for waiting on his housemates
and firing their furnace,
Julian could have a room in the basement.
He soon felt at ease in the fraternity.
The classroom was a different matter.
ANDERSON:You sit in a classroom with kids who have read things
that you never heard of.
They've taken math courses that you haven't taken,
and so one of the academic challenges
is to try to hold on until you can catch up.
VANCE:For two years Julian would take remedial classes
at a local high school
in addition to his normal course load.
JULIAN:I remember writing to my father,
"I know you and Mother have always known
"what was best for me,
"but I think you made a mistake by sending me
to compete with these white students."
VANCE: But by his sophomore year,
Julian was gaining fast on his white classmates,
thanks in part to the encouragement
of chemistry professor William Blanchard.
Blanchard had what one studentcalled "a contagious enthusiasm
for discovering the unknown."
Under his tutelage,
Julian began to dream of a career
as a research chemist.
Only one African-American had ever earned a doctorate
in chemistry.
His name was St. Elmo Brady.
Julian decided that if Brady could do it, so could he.
After four years,
he graduated Phi Beta Kappa and first in his class.
JULIAN: At commencement time,
my great-grandmother bared her shoulders
and she showed me for the first time
the deep scars that had remainedfrom a beating she had received
when one day during the waning days of the Civil War,
she went through the Negro quarters and cried out,
"Get yourselves ready, children, the Yankees are coming!
The Lord has heard our prayers!"
And then, proudly, she took my Phi Beta Kappa key
in her hand and she said, "This is worth all the scars."
VANCE: Encouraged by Percy's success,
his father moved the whole family north to Greencastle
to send the rest of the children to DePauw.
Eventually, Julian's two brothers would become doctors,
and his three sisters would earn master's degrees.
JULIAN: I shall never forget
an anxious week of waiting in 1920
to see if I would get into graduate school.
I stood by as day by day,
my fellow students in chemistry said, "I'm going to Illinois,"
"I'm going to Ohio State," or "I'm going to Michigan."
"Where are you going?" they asked.
And they answered for me:
"You must be waiting for the Harvard plum."
I could stand the suspense no longer.
I went to Professor Blanchard,
and there he showed me numerous letters from men
who had really meant "God" to me;
great American chemists of their day.
"Discourage your bright-colored lad," they wrote.
"We couldn't get him a job when he's done,
"and it'll only mean frustration.
"Why don't you find him a teaching job
"in a Negro college in the South?
He doesn't need a Ph.D. for that."
(train whistle blares)
ANDERSON: What happened to Julian
was something that would havebeen common throughout the land.
To have a good college education was way beyond anything
that one would expect for an African-American.
And so there's the sense that he'd had enough.
"Stop here.
"Be content with this.
Go back and teach your people."
(train chugging, whistle blaring)
VANCE: In 1920, Julian reluctantlyreturned to the South to teach,
but he clung to the dream of earning his Ph.D.
At 21, he was embarking on a quest
that would last more than ten years.
His first stop was Fisk University in Nashville,
one of the best Negro colleges in the country.
His idol, St. Elmo Brady, had studied at Fisk.
But Julian chafed at the limitations
of the Black college system:
overcrowded classrooms, inadequate libraries,
and poorly equipped laboratories.
After two years, he was on the move again.
Julian had won a scholarship to study chemistry
at one of America's most famous universities.
JULIAN: No Negro has yet obtainedhis master's degree in chemistry
at Harvard, and so I'm upagainst a hard situation again.
♪
ANDERSON: When Julian arrived at Harvard in 1922,
the racial climate was probably worse than it had been
at any point in the 20th century.
VANCE:President Abbott Lawrence Lowell had set the tone
by banning Black studentsfrom the dorms in Harvard Yard.
Julian sailed through his first year
and earned his master's degree in the spring of 1923.
He continued his studies
for three more years, but left Harvard without his doctorate.
Years later, he would bitterly tell friends
he had been denied the teaching assistantship
he needed to stay in school.
ANDERSON: If you were going to be a teaching assistant
and teach white students, that was a no-no.
That's just hardly acceptable at that time and that place.
If you were denied that,
you were also denied the opportunity
to finance your education.
VANCE: Julian spent an unhappy year teaching
at a small Black college near Charleston, West Virginia.
Then his fortunes turned.
He was invited to join the faculty
at the nation's mostdistinguished Black university:
Howard University in Washington, D.C.
He was replacing St. Elmo Brady, who was returning to Fisk.
Julian went straight to work,
designing a new chemistry building and honing
a distinctive lecture style.
JULIAN: I should warn you
that scientists are traditionally poor speakers,
because they have a hard time
letting go of their gobbledy-gook.
"Ladybird, ladybird, fly away home"
becomes impossiblewhen you must call the ladybird
"Coccinella bipunctata."
(laughter)
VANCE: Despite his growing stature at Howard,
Julian was still determined to earn his Ph.D.
In 1929, he finally got his chance.
He won a fellowship
that allowed him to take a leave from Howard
to study at the University of Vienna in Austria.
He was about to begin a lifelong inquiry
into the chemistry of plants.
PETSKO: For thousands of years,
long before there was such athing as a science of chemistry,
people were fascinated by plants
because they knew that plants contained substances
that could affect people.
Coffee will keep you awake.
Tobacco contains something that will calm your nerves.
Foxglove contains an extract that'll affect your heart.
And the whole goal of chemistry
in the early part of the 20th century
was to understand what these natural products were,
to characterize their chemical structures
and figure out how to make them.
This was called "natural products chemistry."
It was the main branch of chemistry.
And in 1929, Vienna, in Austria,
was the seat of natural products chemistry.
And that's why Percy Julian went there.
♪
VANCE: Julian arrived at Vienna's Chemische Institut
with huge crates of ground glassware,
items the Viennese students had heard about but never seen.
Yes, yes.
BERNHARD WITKOP: The unpacking became a big ceremony
surrounded by fellow students, who oohed and aahed
about the wonders that came out of these crates.
VANCE: Among the onlookers was Josef Pikl,
a chemist who would become one of Julian's closest friends
and collaborators.
They had come to Vienna
to study under the renowned scientist Ernst Spaäth.
Spaäth was a giant in the field of natural products chemistry.
He had a particular interest
in a family of compounds called alkaloids.
PETSKO: Of all the natural products,
the ones that fascinated people the most were the alkaloids
because they seemed the most powerful.
A thimbleful of some alkaloids would bring down an elephant.
VANCE: It's believed that many alkaloids evolved
to protect plants from organisms that might eat or harm them,
but these same compounds
can have unexpected effects on people.
PETSKO: We now know, for example,
that it's an alkaloid, caffeine, that's responsible
for the stimulant effect of coffee beans.
We also know that it's an alkaloid called nicotine
that's the calming influence in tobacco plants.
Other alkaloids are things like morphine, strychnine, cocaine.
A whole host of things that we now know are drugs,
turn out to be plant alkaloids.
VANCE: By 1929, it was known that an alkaloid
from the root of a common Austrian shrub
called Corydalis cava was effective
in treating pain and heart palpitations.
Spaäth asked Julian to find out why.
DAGMAR RINGE: And so the question was
which compound, which precise compound in this tuber,
is responsible for the biological effect
that one is seeing?
VANCE: Isolate the active ingredient in Corydalis cava,
and then identify its chemical structure;
this was the challenge Julian would have
to meet to earn his Ph.D.
Free at last of teaching and administrative duties,
he threw himself into his research as never before.
JULIAN: For the first time in my life,
I represent a creating, alive and wide-awake chemist.
I recognize that publications and research will be, for me,
as natural a thing as going to bed and eating a meal.
Truly, I was the luckiest guy in all the world to land here.
VANCE:Just outside the laboratory was a vibrant world
Julian was eager to explore.
A fellow student, Edwin Mosettig,
took the American under his wing.
Soon Julian was joining the Mosettig family for ski trips,
swims in the Danube and the opera.
♪
WITKOP: The mother of Edwin Mosettig was a famous musician,
and the Mosettig house was a center
for social activity.
So in that way, Percy got access
to layers of the society
that were inaccessible
in America.
Black persons in Europe
were very rare,
and Percy, for the first time in his life, fully unfolded,
because he was admired there.
VANCE: In letter after letter,
he described his busy social life
to colleagues back at Howard.
JULIAN: And now a little news: I have the prettiest girl in Vienna.
You have never gazed on such beauty.
Monday night, we were in the opera
and heard Beethoven's "Fidelio."
Nature makes its demands,
so I've made a date with my little German sweetheart.
They didn't lie when they talked of beautiful Viennese women.
...sweetest wine cellar you ever saw
and drank till 3:00 a.m.
♪
VANCE: But at 7:55 each morning,
Julian was back in the laboratory,
working under the watchful eye of a man so severe,
he would immediately fail a student
he considered lazy or untalented.
The pressure was mounting on Julian
to isolate the elusive alkaloids
on which his dissertation depended.
JULIAN: The last two months,
I have passed through a hellish siege of work.
Reaction upon reaction,
and yet I stand at the door and knock, as it were.
I don't know a damned thing.
VANCE: The alkaloids that puzzled Julian,
like most of the molecules of life,
are made, primarily, of carbon.
Carbon is really the Super Glue of the chemical world,
in the sense that carbon can bond to itself
in almost an infinite number of ways.
RINGE: In this model, for instance, I can make a chain
of carbons that continues, practically infinitely.
However, it can also come together
into a ring structure,
in this case a six-carbon ring structure.
VANCE: The carbon ring is one of nature's
fundamental building blocks,
found in an endless variety of compounds.
Members of the alkaloid family
all have one or more nitrogen atoms.
But otherwise their structures vary widely,
which presented Julian with a formidable challenge.
NED HEINDEL: He was working in some very difficult chemistry.
When you don't know anything about what the structure is
of the material you're isolating,
you have to tear your molecule apart, atom by atom,
and try to deduce the structure.
RINGE: It's like finding a needle in a haystack.
It requires stubbornness.
It requires focus.
It requires repeating, over and over,
the same kinds of processes,
until the answers come out.
VANCE: Slowly, the answers did come.
In his second year,
Julian finally identified the active alkaloid
in Corydalis cava, his first chemical triumph.
This work with Spaäth would be the foundation
of his future career.
WITKOP: When Ernst Spaäth
was asked about his student, Percy Julian,
he characterized him and said,
"Ein ausserordentlicher Student
wie ich in meiner Laufbahn noch nie gehabt habe."
"An extraordinary student, the likes I have never had
before in my career as a teacher."
VANCE: Julian returned to America
in the fall of 1931,
with the doctorate he hadpursued for more than a decade.
The years in Vienna had dramatically increased
his self-confidence.
But they had also sown the seeds of a personal catastrophe
that awaited him at Howard.
♪
Back in Washington, Julian set out to turn Howard
into a center for true chemical research,
something his predecessor had been unable to do.
Burdened with teaching responsibilities,
St. Elmo Brady had not published a single research paper
in the 15 years since earning his Ph.D.
Julian was determined this would not happen to him.
JULIAN:I am going to give every damned ounce of my energy
towards plans to flood the chemical market
with as much research as the day's hours
and my strength will allow.
VANCE:He brought Josef Pikl over from Vienna,
and the two went straight to work on a series of papers.
When their first was accepted for publication,
Julian proudly noted it was the first
with a Black chemist as senior author.
Percy Julian was now America's preeminent Black chemist
and, at Howard, one of PresidentMordecai Johnson's rising stars.
But Johnson had made many enemies
in his five years at Howard.
Soon Julian would be caught up
in university politics,
with disastrous results.
The trouble began when Julian,
at the president's request, goaded a white chemist
named Jacob Shohan into resigning.
(shouting)
Shohan retaliated by releasing to the local Black press
the letters Julian had written to him from Vienna.
Julian's accounts of his romances,
his criticism of faculty members,
suddenly it was all public,
ammunition to be used against Julian and Johnson
by the president's enemies.
JULIAN: I have the prettiest girl in Vienna...
(overlapping voices)
VANCE: Just as Julian's letters began to appear in the press,
there was another bombshell.
His laboratory assistant, Robert Thompson,
charged he had found his wife and Julian together.
Lawsuits flew between Julian and Thompson.
When Thompson was fired for going public with his charges,
he released the letters that
Julian had written to him from Vienna.
JULIAN: ...and drank till 3:00 a.m.
Edwin and I were all stewed, and the girls were...
VANCE: Through the summer of 1932,
the "Baltimore Afro-American" published letter after letter
from the man the newspaper dubbed
"Howard's Prize Letter Writer."
Finally, under pressure from Johnson
and the Board of Trustees, Julian resigned.
♪
It was the middle of the Great Depression.
Julian was a chemist
without a laboratory,
a Black man without a job.
Only a year after his triumphant return from Vienna,
the career he'd worked so hard to build
was in ruins.
♪
When all seemed lost, Julian's mentor, William Blanchard,
threw him a lifeline,
bringing him back to DePauw
as a research fellow to supervise lab sections.
It was a big step down from full professor
and department chairman, but he had a lab again,
and his research partner, Josef Pikl,
would join him at DePauw.
JULIAN: In much of my life I've hadto pick up the broken fragments
of chanceand turn them into opportunity.
VANCE: Over the next three years,
11 of the student projects Julian supervised
would lead to papers in
the "Journal of the American Chemical Society."
HEINDEL: Eleven undergraduate papers published in "JACS,"
out of a student body of that size,
was not only unusual for the1930s, it would be unusual now.
Julian took the talent in those students
and put that institution on themap for undergraduate research.
VANCE: DePauw's newest instructor left a powerful impression
on undergraduate Ray Dawson.
RAY DAWSON: He put on a grand show.
He would come into his lectures
in his white lab jacket, with a flourish.
He was oratorical in a way that some great scientist
from London or Berlin might be.
It was just a show,
(chuckles) but a very good one.
VANCE: Julian had finally found fulfillment,
a place where he could teach and research.
But when the local American Legion assailed the school
for hiring a Negro who had been dismissed
from Howard University, Julian was forced to stop teaching.
He could stay on as long as his research grant lasted,
but his days at DePauw were numbered.
Everything he'd worked for was about to collapse again.
JULIAN: I decided I had to do things
that would make people take more notice of me.
VANCE: What he did was take on a high-stakes research project,
one that would either make him or break him.
JULIAN: It all began with a simple little bean, the Calabar bean.
Mmm, it was a beautifulpurple bean when I first got it.
But it is not only beautiful in its appearance,
but also in the laboratory it has within it.
VANCE:Chemists had been fascinated by the Calabar bean
ever since British missionaries brought it back
from Africa in the mid-1800s.
From the bean, they had isolated an alkaloid
called physostigmine, used to treat glaucoma.
But no one had been able tosynthesize the complex molecule.
PETSKO: Synthesis is the process
of making a natural product,
or some other substance, artificially, in the lab,
one step at a time,
from extremely simple building blocks.
VANCE: Synthesis was the highest calling
for a chemist in the 1930s.
A successful synthesis could bring great medical benefits,
by making a scarce natural product more widely available.
Just as important, it proved beyond a doubt
that the chemist understood how the molecule was put together.
HEINDEL: There were very few alkaloidsthat had been made from scratch
in Julian's time.
The synthesis of physostigmine
would bring recognition to whoever achieved it.
And that's what Percy Julian set out to do.
VANCE: But Julian was not alone.
At Oxford University, another chemist
was at work on his own synthesis.
His name was Robert Robinson.
HEINDEL: Sir Robert Robinson was sort of the dean
of organic chemists in England.
He was a much-respected creator of molecules,
a trainer of many Ph.D. students.
He was the premier organic chemist of his time.
VANCE: Moving step-by-step toward a final synthesis,
Robinson had already published nine papers on physostigmine
in Britain's leading chemical journal.
HEINDEL: It's a little bit of intimidation.
The world is supposed to know,
"I've got this domain. You stay out of it."
VANCE: But to Julian, Robinson's approach seemed clumsy.
Convinced there was a simpler way,
he set out to beat the Englishman to the synthesis.
A high-profile scientificvictory would be just the thing
to get his career back on track...
but it wouldn't be easy.
Physostigmine was unlike any molecule
that had been synthesized before.
HEINDEL: It bristled with spots around the molecule
where methyl groups were hanging;
that's a carbon with three hydrogens.
There are actually four of these,
and getting them in the right place is essential
to making nature's molecule.
It was a formidable chemical challenge for anybody
to tackle in the early 1930s.
♪
VANCE: Julian tackled it the way allchemists do: one step at a time.
When you synthesize a molecule,
you start with very small substances,
substances you can buy or that you know how to make already.
You then start assembling those into fragments of the thing
that you're hoping to make in the end;
they're called "intermediates."
And what you're doing is you're following a particular path.
This path takes you from the simple starting substances
all the way to the final product, the natural product.
VANCE: To build his molecule,
Julian drew on a battery of techniques
for manipulating atoms.
HEINDEL: One can heat something to a very high temperature;
that usually gets the atoms vibrating
and makes new bonds possible.
You can oxidize something, you can add oxygen to it.
You can take oxygen out of a molecule;
that's a reduction.
We can expose it to pressure.
Sometimes we can expose it to light
to cajole the atoms to do what we want.
VANCE: At each step, Julian had to verify
that he'd actually made the compounds he intended to.
For this, he relied on a device called a combustion train.
HEINDEL:This technique takes an organicmolecule which contains carbon,
hydrogen, nitrogen, oxygen and burns it.
VANCE:By weighing the resulting gases,
Julian could tell what atomswere present and in what ratio.
PETSKO: How much carbon does it have?
How much hydrogen does it have?
How much nitrogen does it have?
If your compound has the right ratio,
you're a long way towards being sure
you've made what you thought you made.
HEINDEL:And then you repeat this processof purification and of analysis
for each intermediate
until you finally get to the natural product.
VANCE: Julian was under tremendous pressure
to complete the research,
pressure compounded by events in his personal life.
He was engaged.
His fiancée was the woman who'd been at the center
of the Howard scandal,
the former wife of his laboratory assistant,
Robert Thompson.
Born Anna Roselle Johnson,
she was a member of a prominent African-American family
from Baltimore.
She had graduated Phi Beta Kappa
and was now working toward a Ph.D. in sociology.
DAWSON: They'd already set, I believe, two wedding dates,
which he had canceled,
and she told him that this was the last time.
Unless he kept the new latest date,
uh, she would break off their engagement.
And he was quite upset by this,
but he had no choice but to proceed,
because we were only a few weeks away from the end.
VANCE: In 1934, Julian and Pikl sent off their first paper
on physostigmine, outlining a new approach to the synthesis.
Julian attacked Robinson in the beginning lines of the paper.
HEINDEL: To have a young upstart
taking on the pope of organic chemistry
in England, naming him, and coupling the words "failure"
and "embarrassing" and "low yield"
is almost unbelievably aggressive.
In many regards,
that was a pivotal point in Julian's career.
If he were wrong,
he could effectively, almost write off
any research career at that point.
VANCE:Working around the clock, Julianand Pikl synthesized a compound
that was one step removed from physostigmine.
Since that last step was already known,
this would count as a complete synthesis.
But before they could publish,
Robinson struck again with his own synthesis
of the same compound.
He's destroyed me in one fell swoop...
VANCE: The race was over.
JULIAN: He's done it!
The shock was almost unbearable.
We were not the first, just the "me, toos."
Why did he of so much fame,
who didn't at all need the glory,
have to snatch the prize from us?
Suddenly, my eye caught something.
"Look, Josef, he's made a big blunder."
Our crystals melted at about 39° Celsius; body temperature.
Indeed, we were able to melt them by closing them
in our armpits.
His compound melted not at body temperature,
but almost 50 degrees higher.
"He hasn't got it!" I cried out.
HEINDEL:The melting point of a molecule is a fingerprint.
If Julian's melting point is correct,
then Robinson's can't be,
and these can't be the same substance.
And Julian quickly grasps on that and says,
"You've got the wrong compound."
VANCE: Julian hurriedly wrote an addendum to their next paper.
"We believe that the English authors are in error."
This will make us...No!
JULIAN: Josef was a very unhappy man.
"If we are wrong, we areirretrievably ruined," he said.
It hit like a bombshell.
Telegrams came in from all over the world.
My old professor Kohler at Harvard, he wrote:
"I pray that you are right.
If not, the future may be very dark for you."
HEINDEL:Part of what he's just done here is a go-for-broke plan.
He's working as an underpaid assistant
in a liberal arts college.
He desperately needs a break.
VANCE: Now the pressure was on Julian and Pikl
to prove they were right.
DAWSON: Percy was a bundle of nerves,
but yet, he had this underlying drive that didn't permit him
to stop, to run away, to give up.
VANCE: To confirm his synthesis,
Julian needed to take one final melting point.
RINGE: When chemists took a melting point,
they would put some crystals into a capillary tube,
strap that capillary tube to a thermometer,
and then place the complete assembly into an oil bath.
They're looking to determine the exact moment
when the crystals begin to melt.
VANCE:To claim victory over Robinson,
Julian had to show that another set of crystals
from his synthesis melted at the same temperature
as their natural counterpart, 135 degrees.
Melting. JULIAN: 135...
136...
Finished!
HEINDEL: This has got to be the ultimate high.
"I've taken on the master, and I've beaten him."
VANCE: The physostigmine papers were immediately recognized
as a milestone in American chemical history,
an early example of whatchemists call total synthesis--
the complete assembly of a complex molecule
from basic chemical building blocks.
HEINDEL: Julian's pathway to physostigmine
is so simple that it can be summarized
in essentially two publications.
Chemists look at them and marvel at
"How did he do that in so elegant of a sequence?"
JAMES SHOFFNER: To call a process "elegant" means
that the synthesis is achieved
in the minimal amount of steps necessary
in order to bring about a product.
And so that's really to give it the highest accolade
that you can give, that it is elegant.
♪
VANCE: In 1935, Percy finally married Anna in a private ceremony
on Christmas Eve.
As his bride went back East to finish her doctorate,
Julian looked forward to new career opportunities
his triumph would bring.
On the strength of his physostigmine work,
William Blanchard had recommended his protégé
for a permanent faculty position at DePauw.
DONALD "JACK" COOK:If DePauw had recognized Percy's capabilities
and put him on the staff at that time,
it would have been a historical event.
It didn't happen.
VANCE: Julian applied to other universities
with the same result.
Most institutions would not even tolerate, for a second,
having an African-American in the role of a teacher
or faculty.
PEARSON: This was during a time of rampant scientific racism.
There were a number of scholars at Harvard
and other institutions that were doing scientific studies
and reporting that African- Americans did not have
the capacity to do science
because they were actually an inferior race.
VANCE: In early 1936,Julian's research grant ran out.
Now with no hope of an academic career,
he turned his attention to industry.
America's leading chemical corporation, DuPont,
had invited Julian and Pikl for an interview.
DuPont executives offered Pikl a job.
To Julian, he later recalled, they offered an apology:
"We didn't know you were a Negro."
The world of chemical research and development in industry
in this period
was overwhelmingly white Anglo-Saxon Protestant men,
and outsiders were not really all that welcome.
VANCE: At Julian's insistence,
Pikl took the job at DuPont
and spent the rest of his career there.
Julian returned to the job hunt.
JULIAN: Day by day, as I entered these firms,
presented my credentials and asked for a job,
the answer almost seemed like it had been transmitted by wire
from one firm to the other.
It ran like this:
"We've never hired a Negro research chemist before.
We don't know how it would work out."
(chuckles)
VANCE:Finally, Julian caught a break.
The Institute of Paper Chemistry,
in Appleton, Wisconsin, was prepared to make him an offer.
JULIAN: And then they were informed by city attorneys
that an old Appleton statute forbade Negroes
from being housed in Appleton overnight.
This, in the year of our Lord, 1936.
But in that meeting sat a board member,
an Irishman named William J. O'Brien.
VANCE: O'Brien was vice president of the Glidden Company.
He'd been looking for a sharp chemist
to run the company's new Chicago laboratory.
He offered Julian the job of Director of Research.
JULIAN: I had already wired Anna several times
that I had landed jobs,
so this time I was a little more cautious:
"Am considering offer Glidden Company
in research at $5,000."
Her reply came back: "What do you mean 'considering'?"
(laughter)
SMITH: The fact that Percy Julian was hired
to be the director of a laboratory,
not just a member of a laboratory,
is truly remarkable and unprecedented.
That was ten years before Jackie Robinson, you know?
And we look toward the Jackie Robinson example
as being pivotal in opening up not just baseball,
but whole lots of otheropportunities for Black people.
And so I came to Chicagoand started in on another
fascinating plant, the soybean.
♪
VANCE: Neither Julian, nor anyone else in 1936,
had any idea what a powerhouse the soybean would become.
Today the soybean is one
of the pillars of American agriculture,
second only to corn among the major crops.
70 million acres of farmland are planted in soy,
with an annual harvest worth more than $20 billion.
Soy is used in a wide range of products,
from food and medicine to paper and plastics.
TODD ALLEN: It's a very widely used commodity.
If you go down to the grocery store and look at the label,
you'll find soybean oil in there somewhere.
Soybeans originally came into this country from China,
as a hay crop
for grazing, for beef cattle.
But, also, it manufactures its own nitrogen,
and back in the 1920s, well, then everybody needed that,
because we didn't have a lot ofcommercial fertilizer back then.
But then, as our machinery developed,
we learned that we could cut and process these soy beans
and break them down into feed for our animals
and soy oil for human consumption.
VANCE: But soybeans really took off in the 1930s,
when industry discovered the plant, thanks, in part,
to the efforts of an unlikely champion:
automaker Henry Ford.
Ford planted thousands of acres of soybeans,
and alongside his Dearborn auto plant,
he built a soybean laboratory and processing factory.
SMITH: Ford sets up a laboratory
in the early 1930s,
hires a young,
self-trained chemist to run the laboratory,
and they begin doing lots of experiments
trying to figure out how you could use
soybeans in making cars.
VANCE: Out of his lab came new
soybean-based auto paints, lubricating oils
and soybean-based plastics
that Ford turned into steering wheels,
gearshift knobs
and dent-proof fenders.
ANNOUNCER:Industrial chemists are working
to find new uses for soybean oil and soybean meal.
VANCE:Soon, other industrialists were following Ford's lead,
building soybean processing plants across the Midwest.
One of the first to embrace the "miracle bean"
was Percy Julian's new boss,
Adrian Joyce of the Glidden Company.
Under Joyce, Glidden had grown from a single paint store
in Cleveland into one of the nation's
leading paint manufacturers.
SMITH: But Joyce didn't stop there.
He diversified into a wide range of products.
Durkee Famous Foods was a Glidden brand.
He also moved into soybean processing.
VANCE: Convinced the soybean would be critical to Glidden's future,
Joyce set up a new Soya Products Division in Chicago.
The first assignment for his new research director:
isolate the protein of the soybean,
something that had never been done on an industrial scale.
Julian plunged into his new job,
keenly aware that people were watching to see
how this Black chemist would measure up.
PETER WALTON: The people in the plant
were always mindful of a white laboratory coat,
a blur that might swoop down at any moment.
PRINTY: He would pester you at many times.
He would keep, you know, wanting to know what was new,
every half an hour, almost.
And he expected you to tell him something different
every time he came in there, something that was favorable.
VANCE: But for more than a year,
the news was not favorable.
WATTS: In chemistry,
things don't ever go the way you plan it,
because you've got reactions that are very critical;
even a little variation in temperature, in concentration
and time, and everything
will give you a bad outcome.
VANCE: Eventually, Julian's chemistsfound just the right combination
of time, temperature, and acidity
to pull the protein out of the soybean.
Julian's "Alpha protein" was the first vegetable protein
produced in bulk anywhere in America.
It made millions for Glidden
as a new industrial paper coating.
ANNOUNCER: Goes on smoothly even on damp walls...
VANCE: Later it would be a key ingredient
in one of the first water-based, or "latex" house paints,
Glidden's Spred Satin.
ANNOUNCER: Get new Spred house paint.
VANCE: After Alpha protein, Adrian Joyce urged Julian
to turn his attention to other parts of the soybean.
SMITH: Joyce was always trying to figure out
every possible use for everything you have.
Find out, "Is there some chemical in here
"that we otherwise might be throwing down the drain,
that we might be able to make money out of?"
VANCE: Julian drove his staff to turn the soybean inside out.
ARNOLD HIRSCH: Julian wanted everyone
to perform to the best of their ability,
and he did everything in his power
to motivate people to do that.
You call yourself a chemist? Yes, Doctor.
JAMES LETTON: I always thought he was a master psychologist.
I think he was very much aware of what he was doing
and who he was doing it to.
WATTS: His purpose was to get the best out of you.
I think that-that's what it was all about.
VANCE: The chemistry invented by Julian and his team
led to scores of new products.
From soybean oil came lecithin,
to make chocolate smoother,
new salad oils and shortenings for Durkee,
and a new non-spattering margarine.
Always when you wereworking on one thing,
there was anotherthing coming up.
You were always thinkingahead of time,
what was the next big thing?
VANCE:From soybean meal came plastics,
linoleum, plywood glue,
high-protein livestock feed, and dog food.
PRINTY: Oh, he was brilliant.
He would set out a research project,
and he would write the introduction
and the description of the work, and a conclusion.
He did everything exceptdo the experiment.
And there would be a statement something to the effect
that, "The problem is solved;
all that remains to be done is..."
And many of us used to cringe at this,
because it would be our responsibility
to get this to work, and sometimes it didn't work.
He was very demanding.
And that was on a daily basis,
I mean, because he had his hands on everything that went on.
ANNOUNCER: Yes, there's magic in this Cinderella crop,
and we've hardly scratched the surface.
VANCE: The stream of products coming out of Julian's lab
joined the flood of household
and industrial goods from Dow,
DuPont and other companies
whose chemistry was changing the way Americans lived.
ANNOUNCER: ...nylon stockings, introduced in 1938.
There's barely a minute of your time on Earth
that is not in some way made
secure and comfortable through chemistry.
SMITH: There was a tremendous amount
of enthusiasm for chemicals
in the 1930s.
ANNOUNCER: Here are the headquarters of a group of super-sleuths,
engaged in solving some of themajor mysteries of the universe.
They take molecules apart and put them together again,
in a different form, to make new and incredible things.
SMITH: People saw the industry
as sort of the leading edge of high technology,
of providing goods and services that were going to make
people's lives better
and to keep the economy growing.
♪
ANNOUNCER:The nation's industrial skyline parted in the middle,
to make room for the growing chemical industry.
VANCE: Glidden's new soybean division was a success.
Julian's reward was a raise
that allowed him to be reunited with Anna.
For the first three years of their marriage,
she had been back East, earning her Ph.D.
and working in the Washington public schools.
Now she joined Percy in Chicago, at last.
As the couple settled into their new home,
in the Westside community of Maywood,
Anna learned just how driven her husband could be
when it came to chemistry.
"Science can be a hardtaskmaster," she would remember.
"Dinner can be at 7:00 or 11:00,
as far as the true disciple of chemistry is concerned."
Glidden was delighted with Julian's chemistry,
but Julian was becoming restless.
JULIAN: I was itching to get away from dog foods,
paint and oleomargarine,
and to tackle nature again with more exacting methods.
PRINTY: Dr. Julian loved chemistry.
He used to take the people that were working on the products
for the Glidden Company and sneak us off
and do other things that he was interested in, on the side.
VANCE:Julian was especially interested
in a compound called progesterone.
ANNOUNCER: New ways of controlling fertility
have begun to suggest...
VANCE: Discovered in 1934, progesterone was called
the "pregnancy hormone,"because it plays a central role
in preparing a woman's uterus for childbirth.
PRINTY:Apparently, Mrs. Julian had had a couple of miscarriages.
And doctors at that time
had found that progesterone was essential
to carrying a child to term.
The pains are getting harder.
VANCE: In the 1930s, nearly one out of every six
pregnancies in America ended
in miscarriage or premature birth.
Relax. Your baby is almost here now.
VANCE:Hundreds of thousands of babies were lost each year.
(baby crying)
Julian realized that progesterone offered new hope.
He and other chemists began looking for ways to make
the hormone for pregnant women at risk.
Progesterone is one of a class of compounds called steroids,
which scientists were just beginning to realize
played many key roles in the body.
PETSKO: They were involved
in reproduction.
They were involved in sexual development.
They were involved in the response to injury and growth.
And yet, despite this enormous range
of different physiological effects,
these compounds all seemed
to have similar chemical structures.
The group of molecules that we call steroids
all share a common framework,
composed of these four ring systems right here:
a six-membered ring fused to a second six-membered ring
fused to a third six-membered ring
fused to a five-membered ring.
VANCE: Dozens of steroid molecules are made by the body,
ranging from cholesterol to digestive fluids
to sex hormones such as progesterone and testosterone.
The anabolic steroids used by some athletes today
are simply modified forms of the natural male hormone.
HEINDEL: Once it was recognized
that the family of materials we call steroids
had such an impact on human health,
there became a global push:
"Can we get these materials?
Can we make them available?"
And, "What sources do they come from?"
VANCE: Chemists first tried isolating steroids
from animal extracts like horse urine,
but the process required vast amounts of raw material
and yielded only tiny amounts of steroids.
PETSKO: The breakthrough, in making steroids available,
was the realization that you could take substances
from plants that could form
the starting point for the synthesis of steroids.
That would give you a leg up on the process.
VANCE: By the mid-1930s, scientists had discovered
that plants have steroids, too,
with the same four carbon rings found in animal steroids.
RINGE: It was only a very
small leap to realize
that one could convert a plant steroid
into an animal steroid.
♪
VANCE: The idea that plants made chemicals
similar to human steroids
was something Julian already knew.
Back at DePauw,
while researching physostigmine,
Julian had set aside a dish of Calabar bean oil.
A few days later, he found white crystals in the oil.
Searching the literature, he found that these crystals
were a plant steroid called stigmasterol.
Small amounts of stigmasterolwere also found in soybean oil,
and Julian now had plenty of that at Glidden.
He was confident that he could convert it into progesterone
if he could find a way
to extract this stigmasterol from the oil.
But Julian was not the only one
who saw the potential of making steroids from plants.
In 1938, a chemistnamed Russell Marker found a way
to convert steroids from sarsaparilla root
into progesterone by chemically snipping off the side chain
of extra atoms from the plant steroid.
It was breakthrough chemistry,
but progesterone made from sarsaparilla root
was too expensive to be practical.
The race was on for a cheaper source.
PETSKO: I think that both Percy Julian
and Russell Marker understood the medical implications
of what they were trying to do.
That they knew if those natural products
could be provided in quantity,
that the face of medicine would be changed.
VANCE: Marker published paper after paper,
documenting his search for a plant
that would yield cheap progesterone.
Julian saw his chance slipping away.
There wasn't much time for this kind of research
amid the daily demands of his job.
JULIAN: One day, the phone rang.
The fellow said, "Doc, something's happened.
"Some water's leaked into Soybean Oil Tank Number One,
and it's spoiled."
Spoiled?
I said, "Spoiled?"
What... what do you mean, spoiled?
Now, you understand,
this tank contained 100,000 gallons of refined soybean oil
bound for the Durkee Famous Foods plant.
If it were ruined, Glidden would be out $200,000.
And such a blunder might cost me my job,
so I was over there in a jiffy. (laughter)
♪
VANCE: Julian found the giant tank fouled with white sludge.
But his despair vanished in a flash of recognition:
There were crystals in the sludge
at the bottom of the tank.
They were stigmasterol, the same crystals he'd found
in the dish of Calabar oil.
Now he realized what had forced the stigmasterol
out of both oils: water.
COOK: You couldn't destroy
a 100,000-gallon tank of soybean oil
to get this steroid out.
But, when you add a little water to it, it falls out.
It precipitates; it separates on its own.
JULIAN: And it was this little accidental discovery--
the kind that characterize
the development of science so often--
that led to a practical method for the isolation of steroids
from soybean oil.
VANCE: Now a step ahead of Marker,
Julian developed an industrial process
for converting stigmasterol into progesterone in bulk.
HEINDEL: Julian did not discover the primary chemistry
that took stigmasterol over to progesterone--
that came out of a German group five years earlier--
but he was the first person to realize
that it could be scaled up.
A company that's in the paint business
suddenly becomes a player in the human sex hormone game.
VANCE: In 1940, Julian sent
a one-pound package of progesterone
to the Upjohn pharmaceutical company.
Shipped under armed guard, and valued at nearly $70,000,
it was the first commercial shipment
of an artificial sex hormone produced anywhere in America.
Testosterone and other artificial sex hormones
soon followed, bringing millions of dollars
in unexpected revenue to Glidden.
Despite his growing stature, Julian was barred
from a major hormone conference
held at an exclusive resort in Maryland.
Only after three days of protest by his white colleagues
was he finally admitted.
♪
Within a year, Julian would face a new challenge.
His rival, Russell Marker,
had discovered that a giant yam in Mexico
was even richer in steroids than soybeans.
In 1944, Marker and two partners formed a company
called Syntex to make hormones from the yam.
For the rest of the decade,Syntex and Glidden would produce
most of the world's supply of artificial sex hormones.
PETSKO: I think the decision to make substances like steroids
from plants,rather than from animal tissues,
was a landmark in the history of medicine
as well as the history of chemistry.
It meant that you could take steroids
that before were so rare thatyou barely knew what they were,
and you could inject them into animals or people
and see their effects on a variety of conditions.
The possibilities that that opened up
almost were limitless.
VANCE: The work of Julian and Marker would lay the foundation
for a whole new class of medicines,
including the birth control pill
and a wonder drug that would soon take the world by storm.
♪
By the mid-1940s,
Julian's work at Glidden had won him national acclaim.
With the outbreak of World War II,
his Alpha protein became the chief ingredient
in "bean soup," a firefighting foam credited with saving
thousands of servicemen's lives.
He was even featured in "Reader's Digest,"
one of America's most popular magazines.
PRINTY: It was the beginning of white America's exposure
to Dr. Percy Julian, and how he had to fight
to overcome the oddsof being a Black man in America.
And, in the context of the times, it made him a symbol.
SHOFFNER: Here was a person who looked like me
who was not only in the field,
but succeeding magnificently at the top of his profession.
That was profound.
VANCE: Julian was named to the boards
of half a dozen colleges and universities.
He was showered with awards and honorary degrees,
and sought after as a public speaker.
The NAACP awarded him its prestigious Spingarn Medal,
previously given to W.E.B. DuBois,
George Washington Carver,
Paul Robeson, and Thurgood Marshall.
And the "Chicago Sun-Times" named him
"Chicagoan of the Year."
As Julian's stature grew,
so did his personal responsibilities.
Anna had given birth to a son, Percy Jr., in 1940,
and a daughter, Faith, four years later.
With so many demands on Percy's time,
Anna shouldered the parenting duties.
"For the children," she later wrote,
"an after-dinner visit withtheir father was a rare treat."
I hardly remember a weekend when he didn't work,
but the time you had was quality time.
VANCE: By the end of the 1940s,
the family had outgrown their Maywood home.
The Julians began looking for a bigger one
in a neighborhood that suited their new social status.
They set their sights on Oak Park,
one of Chicago's most affluent and exclusive suburbs.
The village was home to doctors,
lawyers, and wealthy businessmen.
It had a reputation as a town
for the educated and enlightened.
VIRGINIA CASSIN: It's always been a community
that was... had a little sense of its importance
as far as being, perhaps, a cut above others.
MAN (on radio): Thanks to our good friends,
the makers of Broadcast brand corned beef hash...
VANCE: Oak Park even had its own radio show,
familiar to listeners all over America
as "Breakfast with the Johnsons."
GIRL (ON RADIO): Daddy, I have to give a report in school,
so I'm gonna give it to you.
Well, these days, they'd call it reality radio,
and that's what it was,
7:30 in the morning, Monday through Friday.
MAN (ON RADIO): Pamela?
JOHNSON: The microphones were all over the house.
The children would wander in, and the milkman would come in.
GIRL (ON RADIO): We were doing imitations. I did Jimmy Durante.
JOHNSON: We talked about us and the world around us.
JOHNSON (ON RADIO): Well, I'm glad to see you're learning how to make money.
VANCE: The world around the Johnsons was cultured, privileged
and white.
The few African-Americans who lived in Oak Park
worked as servants and laborers.
BOBBIE RAYMOND: When the Julians came along, I'm sure that this was a shock
to many people who lived in Oak Park.
Here they are, two very well-educated people,
both with Ph.D.s,
he a very successful chemist and businessman,
and they purchased a house, a large house, on a large lot.
JOHNSON: There was some nasty tongue-wagging going on:
"Who do these people think they are
"that they can move in here
and take over our neighborhood?"
VANCE: Trouble began even before the Julians could move in.
JULIAN, JR.: My dad was out of town, and my mom got a call
from the Oak Park Fire Department.
"Something has occurred at the house,
"this is the fire department,
could you please come?"
Even as a 10-year-old, I knew that this was an arson.
There was no attempt
to hide this,
to make it look like an accident.
I see these bottles,
these huge bottles,
and I could smell gasoline.
The stairs were soaked all the way up to the second floor.
I think my mother was scared.
But if she was, she didn't show it.
♪
They lit the fuse on the outside.
The door caught on,
but it sealed so well
that the flames couldn't get under the door.
But had the bottles caught,
the flames would have gone right up the stairwell--
a natural chimney--
and the house could've been a total loss.
And I looked at my mom, and I said,
"Why would anybody want to do this?"
And she explained it:
they didn't want us to live there,
and didn't want us to live there because
of the color of our skin.
VANCE:Now Percy Julian, accomplished, affluent, ambitious,
was face-to-face with the same violence
African-Americans all over Chicago
were encountering
as they tried to move into white neighborhoods.
VERNON JARRETT: After the war,
when the ghetto was bursting
at the seams and people trying to move out,
every first Negro, they said, to move in a block
was going to catch hell.
A mob would be out there to greet you.
I've seen it, covered it.
VANCE:There were no mobs in Oak Park,
but the arson was a clear warning
that some in the community would stop at nothing
to keep the Julians out.
JULIAN, JR.: The arson attempt
did not succeed in intimidating my mom and dad.
Nor could it have.
They were simply not intimidatable.
JULIAN: Once the violence began,
Anna and I felt we had no choice but to stay.
To leave would have been cowardly and wrong.
The right of a people to live where they want to,
without fear, is more important than my science.
And I was ready to give up my science and my life
to bring a halt to this senseless terrorism.
VANCE: The Julians moved in.
And when a few months passed with no further trouble,
Percy and Anna felt confident enough to go out of town,
leaving the children with a baby-sitter.
(distant dog barking)
♪
Let's go!
JULIAN, JR.: The first my parents saw of it
was when they saw it
in the paper
the next day,
with me pointing to the hole in the ground.
GIRL: But Daddy, I hear that there's...
JOHNSON: I'll never forget the morning that my daughter Sandra said,
"Daddy, they bombed my friend
Percy Julian's house last night."
And then she said, "Daddy, why did they do that?
Why would they bomb their house?"
I put on a record, because I didn't have the answer.
♪
JULIAN, JR.: My dad was angry when he came home,
I mean really angry, and clearly ready to fight.
He looked at this as an attempt to murder his kids.
For him, there was nothing redeemable about them at all.
(indistinct arguing)
I'm taking this in like there's no tomorrow.
And actually, you know how everything has a good side?
The good side was, as a kid,
I got to spend more time with my dad,
and got to stay up late, 'cause we'd sit in the tree outside.
He'd sit there with a shotgun.
And we'd talk about why someone would want to do this
and how wrong it was and how stupid it was.
VANCE: The Julians would continue
to receive threatening letters
for years after.
No one was ever arrested.
Many Oak Park residents were horrified at the violence
against the family.
I think people were shocked
that anyone should be treated that way.
And there were people who came forward to say,
"There are a lot of us that don't feel that way."
JOHNSON: There was at least 200 or more people
that marched right up in front of the Julian house
on East Avenue and said, "He stays, he stays."
VANCE: Even as events in Oak Park
threatened to upend his personal life,
a new scientific challenge was drawing Percy Julian
into one of the great medical dramas of the 20th century.
At the center was one of the oldest
and most painful of humandiseases, rheumatoid arthritis.
CHARLES PLOTZ: "Arthritis" is a generic word
for inflammation of the joints
and encompasses a lot of different diseases.
But the disease that truly inflames the joint
and causes destruction of the cartilage
and the bone within the joint is rheumatoid arthritis.
VANCE: Scientists had been seeking a cure for rheumatoid arthritis
for hundreds of years.
But by the middle of the 20th century
those efforts had yielded
only a bizarre assortment
of mostly ineffective treatments:
chin slings, gold injections,
mineral baths, cobra venom, bee stings,
even electricity.
PLOTZ: People would swear by them,
but nothing, over the long run, worked.
VANCE: The situation changed dramatically
at the 1949 annual meeting of American rheumatologists.
Philip Hench, of the Mayo Clinic, presented a film
showing how arthritis patients responded to a new drug,
called Compound E and later named cortisone.
PLOTZ: They were severely crippled,
having to drink by holding a cup in both hands.
And Philip Hench gave them an injection,
and within 12 to 24 hours, the same patients
were having no difficulty at all.
It was one of the most astonishing things
that has ever happened in medicine.
You didn't need a double-blind study.
You just saw it happen.
And the audience
stood up and cheered.
♪
Well, every patient with rheumatoid arthritis
immediately wanted to be put on this magic drug.
VANCE: The problem was, there was none to be had.
Hench had performed his tests
with a few precious grams of cortisone
sent to him by Lewis Sarett, a young chemist at Merck.
Sarett had worked for years to synthesize cortisone
from the bile of slaughtered oxen.
But his chemical pathway was the most complex
ever attempted in industry, requiring more than 30 steps.
And thousands of cattle carcasses
would be needed to make enough cortisone
to treat a single patient for a year.
To treat the millions suffering from rheumatoid arthritis,
scientists would need to find
a more plentiful starting material
and simplify the process of producing cortisone.
Chemists from all over the world sprang to the challenge,
launching one of the most intensive research efforts
in the history of medicine.
Julian threw himself into the effort.
SMITH:The only reason that Glidden is in the great cortisone race
is because of Percy Julian.
He knows this chemistry,
and so he can establish a position for them.
The American pharmaceutical industry, after World War II,
is not the giant that we know of today.
This business is really just getting going,
so there is room for entrepreneurs in this period.
VANCE: One of those entrepreneurs was Carl Djerassi,
then a young chemist at Syntex, the small Mexican company
that made hormones from yams.
CARL DJERASSI: Julian and I were competitors,
and we were in this race with people at Harvard,
and at Oxford, and in Zurich, and at Merck,
and, I mean, all the major companies.
It was one time when
basic research in industry
competed on equal terms with that in universities.
VANCE: The prize these chemists were after
was not actually a drug but a natural hormone.
Cortisone is one of the many hormones
made by the adrenal glands,
two small organs that lie atop the kidneys.
Small amounts of cortisone are always circulating
in the bloodstream, controlling the body's responses
to stress and inflammation,
but much larger doses of cortisone
were needed to relieve the symptoms of arthritis.
Julian hoped to make cortisone from soybeans,
just as he had the sex hormones.
Like progesterone,
cortisone had the same four interlocking rings of carbon
known as the steroid nucleus,
but cortisone has an unusual feature:
one of its oxygen atoms is inwhat chemists call position 11.
Julian set out to make cortisone by first synthesizing
an almost identical compoundcalled Reichstein's Substance S,
or Compound S.
JULIAN: Look at the two formulae.
Compound S differs from cortisone
by one lone little oxygen atom.
And it couldn't possibly be so strikingly different
in properties, I thought.
And if it is, why in the devil
did nature have to put so much in the adrenal glands?
Well, if you reallythink nature is smart,
your guess would be
that it's there as a reservoir from which the adrenals
can make cortisone as the body needs it,
by simply sticking in this one oxygen atom.
♪
VANCE: Julian hoped to convert Compound S into cortisone,
as the body does,
but he knew that inserting that one oxygen atom
in exactly the right place would not be a simple matter.
PETSKO: In the body,
there's a special enzyme that knows how to do this
and does it very elegantly, in a simple reaction.
But to do this chemically,in the lab, in large quantities,
was fiendishly difficult.
In the laboratory, in order to add any atom
to this carbon atom requires
severe conditions-- high heat, high pressure,
very reactive reagents that will attack this atom.
The difficulty with those conditions is
that they will attack every other carbon atom
on this skeleton as well.
You want to put the oxygen only in that position.
It doesn't do you any good to put it there if,
simultaneously, you put it somewhere else
where it's not supposed to be.
VANCE: Chemists across the world faced the same challenge.
Whatever material they started with, plant or animal,
they had to find a way to insert that one oxygen atom
into just the right position.
This was the single biggest obstacle to making cortisone.
As Julian struggled to find a solution,
Glidden executives were losing patience
with his Compound S approach.
PETSKO: It's hard to read another chemist's mind,
but I think that Julian probably knew
that this was so close to the final structure of cortisone,
that if he could makeSubstance S in large quantities,
inexpensively, he would, eventually,
or someone would, eventually, find a way to insert
that troublesome oxygen into the 11 position,
because that was the only remaining step needed
to convert that substance
into the full-blown hormone, cortisone.
VANCE: But the problem of inserting that one oxygen atom
continued to frustrate chemists for more than two years.
The cortisone shortage became a crisis,
as the price topped $4,000 an ounce,
one hundred times the price of gold.
PLOTZ: I would get requests from all over the country,
"Can't you get me some cortisone?
"Can't you get me a little cortisone for me?
"For my aunt?
For my patient?"
And I couldn't get it, for me or for anybody.
♪
VANCE:Finally, in the summer of 1951, four teams of chemists
announced they had found new ways to make cortisone.
The winners included teams from Harvard, Merck, and Syntex.
We got an enormous amount of publicity,
including "Life" magazine and places like this,
and that put Syntex on the scientific map.
VANCE: But the chemists' glory was short-lived.
Six months later,
they were upstaged by a surprising discovery
from scientists at Upjohn, in Kalamazoo, Michigan.
ANNOUNCER: From laboratories in Michigan
comes the new process for making
unlimited quantities of cortisone.
That bubble of conceit and pride and pleasure
was completely punctured, when we discovered
there were these yokels in Kalamazoo who,
in one step, did something that took us
15 steps-- very clever steps-- to do.
VANCE: These so-called "yokels"
had discovered a common mold
that could effortlessly
insert an oxygen atom into the 11 position.
PETSKO: Upjohn figured out that they could do it
by a fermentation process.
In other words, it wasn't done
in a chemistry lab at all.
It was done by a microorganism that possessed an enzyme
that was capable, just like the human body is capable,
of attaching an oxygen in exactly the right place.
VANCE: Upjohn's discovery was the breakthrough
that would end
the cortisone shortage.
Its mold could work
its oxygen-inserting magic on a range
of steroid materials,
including Julian's Compound S.
PETSKO: All of a sudden,
Substance S was very important.
This compound, that didn't have
any particular important biological activities
of its own, became ideal as a starting material
to produce cortisone.
And Julian was sitting on the process to make that.
JULIAN: Many well-meaning people have exaggerated my contribution
to the chemistry of the cortisone
family of drugs.
I've even read somewhere
that I was "the discoverer of cortisone."
Not so.
But we made a good choice, indeed,
in choosing to synthesize Compound S
as our first endeavor.
Cortisone could now bemade from Compound S
simply by dumping itinto a tank
and throwing in a microorganism
and fishing out cortisone afterthe organism has done its work.
VANCE: But Julian's Compound S
was not the only material Upjohn's mold
could transform into cortisone.
DJERASSI: Suddenly, Upjohn came to Syntex--
I still remember, because I was there-- and said,
"Would you quote us the costof progesterone at a ton level?"
Well, we were completely flabbergasted.
At that time, still, the worlddemand was a few hundred kilos.
VANCE:The request could mean only one thing:
Upjohn had decided to produce cortisone
from progesterone made by Syntex,
not from Julian's Compound S.
Syntex had a big advantage: its starting material,
the Mexican yam, was a richer source of steroids
than the soybean, so cortisone made this way was cheaper.
But other companies were alsogearing up to produce cortisone.
Julian could still win their business,
if he abandoned soybeans
and made Compound S from the Mexican yam.
But when Julian appealed to Glidden's chairman
to make the switch, the answer was, "No."
JULIAN: I begged him to hold on;
we could set up a simple yam processing plant in Mexico,
and with Glidden's influence
we could soon be masters
of the field.
But he had otherplans for me
in paint and varnish chemistry,
new paint to prevent icing on airplane propellers,
new shortenings that didn't spatter.
SMITH: I think the steroid work that Julian was doing
was just one of those little businesses
that no longer were seen as important to the company
and its future direction.
They sent me to Europe,
for a vacation, to forget about it.
And, on my return, the chairman announced that Glidden
was going out of the steroid business altogether.
PRINTY: This was a blow to the heart of Doc.
And he said he didn't know
whether he'd be able to stand that,
because if there was no steroid research,
there was nothing that he could really interest himself in.
VANCE: Joyce licensed Compound S to Pfizer and Syntex
and ordered Julian to teach their chemists
how to use the process he'd invented.
And things kept getting worse and worse and worse,
until finally it just became untenable for him.
VANCE: In late 1953, Percy Julian walked away from the job
into which he'd put the most productive years of his life.
JULIAN: And when I left Glidden,
I left behind 109 patents,
for which I received $109 and other valuable considerations.
(light laughter)
VANCE: One of those patents was for Compound S.
Just as Julian predicted,
it went on to become a key ingredient
in the production of cortisone,
helping to make the drug available to millions
at a reasonable price.
PETSKO: The fact that Julian could do what he did,
while working in a paint company,
strikes me as just remarkable.
He didn't just do these things because glory would be his
if he succeeded.
There always is, in Julian's work,
this sense of aiming for something big,
because it's going to be useful for people.
VANCE: But to fulfill his ambition,
Julian would now have to reinvent himself
as a businessman
in one of the most cutthroat industries in America.
Within a few months, Julian was back on his feet
as president of his own chemical company
in Franklin Park, outside Chicago.
PRINTY:We had left the Glidden Company
and moved out to this place that was loaded with rats
and mice and everything else.
You couldn't eat your lunch without a mouse coming out.
WALTON: Working conditions,
I guess, would be considered primitive.
VANCE: But for Julian it was the chance of a lifetime.
After 18 years at Glidden, he was his own boss,
free to focus on work that excited him.
His plan for success was simple:
Julian Laboratories would make steroid intermediates,
compounds that were often just one step short
of a finished product.
The big pharmaceutical companies would buy them,
because Julian could make them faster and cheaper
than they could.
From his old friends at Upjohn,
Julian quickly landed a contract
for $2 million worth of progesterone.
More business followed fromCiba, Pfizer, Merck and others.
There was just one obstacle:
Syntex, the Mexican company
that now dominated the hormone business.
Syntex controlled the supply of the Mexican yam,
or barbasco root.
Julian needed an extract
from the root to make his intermediates cheaply,
but Syntex refused to sell him any.
It was a setback that threatened the company.
WALTON: Having put it all
on the line with these major pharmaceutical companies,
he had to deliver the goods, had to.
VANCE: To get around Syntex,
Julian would have to build his own
$300,000 barbasco processing plant in Mexico.
Dr. Julian didn't have the necessary capital himself.
The conventional, normal banking sources
were off limits to people of color, period.
VANCE: Using personal savings and money from friends
and private investors, Julian was able to build the plant.
But then, another roadblock:
the Mexican government, closely tied to Syntex,
refused him a permit to harvest the barbasco root.
His expensive Mexican factory was useless.
JULIAN: And there we stood, with our beautiful plant,
our beautifully lighted water tower
with "Laboratorios de Julian de Mexico"
emblazoned on it...
a mausoleum.
I sat in a hotel in Mexico City
wondering whether I should shoot my brains out.
WALTON: There was enormous pressure on Dr. Julian,
because the financial stakes were huge...
were huge.
He had everything invested,
between Franklin Park and Mexico,
and so this was a pressure, pressure time.
And then a strange thing happened.
There was a knock on the door, and in came a man named
Abraham Zlotnik,
a man that I had helped out of Hitler's Germany.
Abe said he was sure the yam grew in Guatemala,
and he volunteered to make an expedition for me.
I told him I was broke, ruined.
I didn't know when I could pay him back.
But he said, "You've already paid me back."
VANCE:Zlotnik was as good as his word.
His expedition found the barbasco root in Guatemala.
Julian now had the raw material he needed to achieve his goal:
making steroid drugs available to all who needed them.
LETTON: He always talked about being able to lower the cost
of some of these anti-inflammatory agents,
these steroids, so that the common man could buy them.
VANCE: Even if it meant lower profits for Julian Laboratories.
One year, his chemists
found a way to quadruplethe yield on a product on which
they were barely breaking even.
LETTON: I thought, personally, that that was a good opportunity
to recover some profits from the low yields
of the previous year.
Instead, he dropped
the price of this stuff from $4,000 a kilo
down to about $400 a kilo.
And I couldn't understand why he would do that.
He wanted to make money, but he also wanted things
to be available for people.
VANCE: Much of Julian's own money was still tied up
in his idle Mexican plant.
To make good on that investment,
he would have to resolve some unfinished business
with an old rival.
Would Dr. Percy Julian come forward?
VANCE: Julian believed Syntex had used its influence
with the Mexican government to keep his factory from opening.
After other American companies made similar charges,
the Senate held public hearings in 1956.
Julian was the star witness.
MAN: Was there any company in Mexico
objecting to your getting a permit?
JULIAN: It became very evident
that the Syntex Company was objecting to the permit.
In fact,Dr. Somlo told me
he would fightto the last
to keep me and anyone else out of Mexico.
VANCE: As a result of the "wonder drug" hearings,
the Justice Department took action against Syntex.
Julian was finally able to open his Mexican plant,
but the mounting pressures of running a business
left him little time to savor the hard-won victory.
Every month there were shipments to make
and severe financial penalties for missed deadlines.
WALTON: We lived, for the most part,
in a highly stressed,
very competitive environment--
a small company, limited resources,
and dealing with a huge industry.
EARL DAILEY:There were many occasions where 2:00, 3:00
in the morning would come,
and you'd still be in the laboratory working.
WALTON: When I complained about the lack of sleep,
Dr. Julian advised me that sleep could be dangerous
for my health.
I could die in my sleep.
"And while you're contemplating that,
"go back out in the plant and continue to work.
We have a shipment to get out."
LETTON: But there was an unusual sense of loyalty
that made people work and want to see him
and the company successful.
How else could you get a crew to work 24 hours a day?
(laughing): That sort of thing.
VANCE: And successful it was.
Julian Laboratories would eventually make its founder
a millionaire,
one of the wealthiest Black businessmen in America.
♪
For his chemists, the reward was an opportunity
hard to find anywhere else:
a chance to work in their chosen field.
LETTON: When I was looking for a job,
some people made excuses, and then there were some
that just said, "We don't hire you people."
TOM WEST: They told me that I was too well qualified
to take a job.
I felt that they were saying,
"Come back maybe another time.
Come back when you're white."
♪
VANCE: Scores of chemists, unwelcome elsewhere,
would use their years with Julian as a springboard
to careers in industry and academia.
WALTON: I'm proud to say that our laboratories in Franklin Park
employed more Black chemists
than any other facility in America.
On the other hand,
for such a small organization
to have such a significant role
in true integration
it's a sad commentary on the state of affairs in America.
VANCE: Outside Julian's lab,
America was still a nation divided by race,
and Julian was constantly reminded of it...
...even at meetings of the American Chemical Society.
EDWARD MEYER: When we went to the meeting,
he said, "Ed, grab me by the arm when we go in,
so people will know that we're together."
Because he was afraid they'd...
being a Black man, they'd throw him out.
VANCE: Neither wealth nor fame could insulate Julian from bigotry.
But with success came the chance to do something about it.
Increasingly, he set aside his science
to fight for racial equality.
He joined the NAACP and the Urban League
in their battle against discrimination
in jobs and housing.
He led a national fundraising campaign
to support civil rights lawyers.
And in speech after speech, he preached that education
and the pursuit of excellence--the hallmarks of his own life--
were the key to Black advancement.
But many younger African-Americans
were impatient with traditional tactics
and rejected the sermons of Julian's generation.
JULIAN: Our children and our grandchildren saw all of this
and suffered for their ofttimes "Uncle Tom" parents
who seemed to be doing nothing about it.
Finally, their pent-up agony exploded on us.
(shouting)
JULIAN, JR.: I would say,
"Explain this to me.
How is it that this is all going to change?"
He would say, "Well, it will.
"There are lawyers, and they're going to fight for change.
And if you set an example, things will change."
Well, uh...
I don't have forever.
VANCE: In the 1960s, Julian's son drove to Nashville
to join the effort to desegregate
the city's lunch counters.
♪
(shouting)
JULIAN, JR.: On the one hand,
he was very proud,
but on the other, he was very scared.
One time he said to me, "You know,
"this is not a game.
These people are playing for real."
And my response was, "So are we."
♪
VANCE: The '60s were an awakening for Julian.
He came to see that the nation could not afford
to wait for the old ways to work.
JULIAN: For more than a century, since the end of slavery,
we have watched the denial
of elemental liberty to millions of Black people
in our southland.
JULIAN, JR.: I think he saw that things
were moving so fast,
that if the country didn't change,
there was going to be serious, serious trouble.
VANCE: By the late 1960s,
Julian had come to supportthe more confrontational tactics
of his son's generation.
JULIAN, JR.: My father wrote, later,
it wasn't going to be enough just to be a model citizen,
to be educated,
to do all the things
that anybody could possibly expect of you,
because none of that would ever change the fact
that you still couldn't go and eat
in a restaurant that didn't want to serve you.
JULIAN: Branded, first, unfit to spend their money
for food or drink in public places
along with other Americans;
denied the ballot and confined to ghettoes
that stifled hope and ambition;
victims of murder of the mind...
...heart...
and spirit.
This is the story of the American Negro.
♪
VANCE: Percy Julian's own story now entered its final chapter.
Born in 1899, he was now in his 70s
and a proud grandfather.
KATHERINE JULIAN, M.D.: I definitely was awarethat my grandfather was special.
I remember playing with a doll
that had been sent to him by a woman,
and the story was told to me why it had been sent.
She had such bad arthritisthat she couldn't use her hands.
And after using cortisone, she was able
to knit this doll and send it to him.
And I remember holding the doll and playing with the doll
and realizing that he had helped her,
and that that was something that was really special.
VANCE: For his contributions to humanity,
Julian received 18 honorary degrees
and more than a dozen civic and scientific awards.
There was hardly any collegethat didn't try to honor itself
by naming Percy Julian as an honorary Ph.D.,
because that was the time when people tried
to make up for past injustice.
VANCE: Julian's longtime friend Bernhard Witkop
envisioned a higher honor.
He secretly began a campaign to elect Julian
to the prestigious National Academy of Sciences.
It was an uphill battle.
We had some prejudicial talk in the Academy, by old timers.
Some were very famous people and Nobel Laureates
who couldn't get used to the new situation.
VANCE: Witkop persisted,
and in 1973, Julian received an unexpected phone call
from the Academy's home secretary.
WITKOP:He said, "Sir, may I inform you
"that you have just been elected
"a member of the National Academy.
Congratulations."
VANCE: Julian was only the secondAfrican-American to be elected.
It was the crowning recognition
of 40 years of chemical research.
HEINDEL: If you look at Percy Julian's career,
you can say if this man had not been Black,
he could have been a chaired professor
at any Ivy or Big Ten institution.
The breadth of his understanding of chemistry
and his fire in the belly to produce so many results
in such a short period of time--
this is Nobel Laureate stuff.
♪
VANCE:Looking back in an autobiography he would never finish,
Julian offered his own assessment
of his life in science.
JULIAN:I feel that my own good country
robbed me of the chance for some of the great experiences
that I would have liked to live through.
Instead, I took a job where I could get one
and tried to make the best of it.
I have been, perhaps, a good chemist,
but not the chemist that I dreamed of being.
VANCE: In April 1975,
a week after his 76th birthday,
Percy Julian died of cancer.
His pallbearers included the chemists
who had been his friends and colleagues.
Every year, the U.S. Postal Service
issues a commemorative stamp
to honor an African-American leader.
In 1993, the choice was Percy Julian.
PRINTY: As a human being, I think that he was
a source of inspiration to many, many, many people.
VANCE: In 1999, the American Chemical Society
recognized Julian's synthesis ofthe glaucoma drug physostigmine
as one of the top 25 achievements
in the history of American chemistry.
The plaque is housed
in the new Percy Julian Science Center at DePauw.
ROBINSON: For him to have accomplished what he did,
with the resources that he had, is still amazing.
VANCE: Across the world today,
millions of people benefit from steroid medications
based on the chemistry of plants.
Some of these drugs are still made from soybeans,
using chemical steps much like those Percy Julian pioneered.
PETSKO: Here was a man who not only had to overcome
the disadvantages of his race, but who,
throughout his entire life, was in a situation
that was never ideal for doing the big things
he was trying to do.
Looking over his life,
one has a sense that hereis a man of great determination.
And it's a determination not just to succeed,
but a determination to make a difference,
to make a contribution.
ANDERSON: His story is really a contradictory one.
It's two stories.
It is a story
of great accomplishments, of heroic efforts
and overcoming tremendous odds.
But it's also a story of talent squandered,
of potential stifled.
It's a story about this country.
It's a story about who we are
and what we stand for
and the challenges that have been there
and the challenges that are still with us.
♪