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Xand van Tulleken, Raksha Dave and John Sergeant discover the parallels of the Great Plague of 1665 with the Covid-19 pandemic. Ch1. Outbreak The epidemic is traced back to its source in the parish of St Giles in the Fields, now at the heart of London's theatre district. The program also examines the symptoms of the disease and uncovers new research into the plague bacteria that could overthrow accepted ideas about how the infection was spread. Ch2. Decimation Xand heads to St Barts hospital to look back at historical records which show that nursing staff stayed behind and risked their lives to help the sick. Elsewhere, John investigates why infection rates were so different between the rich and poor, examining clothes typical for each group in the 17th century. Ch3. Aftermath Xand visits Samuel Pepys' parish church and discovers the sad tale of the Poole family, who within 11 days lost all five of their children. He also heads to Eyam in Derbyshire, revealing the heroic story of self-sacrifice that saw all 700 villagers lock themselves in to try to stop the disease from spreading to surrounding areas. Raksha Dave trials 17th-century disinfection methods and reveal a surprising substitute that can be just as effective as modern antibacterial cleaners.
2020 • Health
What happens when microbes talk to your brain?
In a Nutshell • 2017 • Health
For centuries scientists have been attempting to come up with an elixir of youth. Now remarkable discoveries are suggesting that ageing is something flexible that can ultimately be manipulated.
Follows two patients through groundbreaking 'first in-human' trials for CAR T-cell therapy, a treatment described as the beginning of the end of cancer. Not allowed to meet and separated by two floors of a hospital, 53-year-old Graham and 18-year old-Mahmoud are nevertheless bound together by their commitment to the treatment and their faith in the science. Terminally ill, the trial represents their only option. How do their ages and life experiences affect their physical and emotional response? For Martin Pule, the scientist who has developed the treatment, the responsibility of curing patients is both exciting and daunting. He knows he stands on the cusp of a breakthrough that could radically change the way we treat cancer. At the heart of this film is the complex relationship between the patients and the clinical team. How much hope can the patients be given when they are effectively going into these trials as human guinea pigs? The patients and clinical team must weigh up hope with realism and their response is a profound and revealing reflection of the human condition.
2019 • Health
Michael Mosley shows how the body performs countless small miracles to stay alive.
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In the early days of the space race, agency researchers in Russia and at NASA really weren't sure all what would happen to an astronaut in space. They didn't know if a human mind could handle actually seeing Earth or what would happen to the human body when exposed to long periods of weightlessness. Would their blood forget which way to pump? Would their eyeballs shift or their inner ears wig out? They sent up mice and monkeys and dogs, to see what happened, and in 1961, the Russians strapped a man to a rocket headed for orbit. Yuri Gagarin was the first person in space. The ultimate human guinea pig, he survived, becoming an international hero.