What new methods of analysis have been developed in the age-old struggle to discover if someone is telling the truth...or not? Some scientists have gone beyond the polygraph to model other ways of detecting whether we are getting a straight answer or being led down a crooked path.
Imagine a world in which you can think but cannot speak. For many stroke survivors, like former football star Junior and landlord Barry, this nightmare is a reality. Inspired by the experience of his brother-in-law, filmmaker Richard Alwyn has made an intensely moving, personal film about language and its loss. Alwyn's brother-in-law, journalist Dennis Barker, had a stroke in 2011 which left him speaking a bizarre, fluent gibberish – just one manifestation of the condition ‘aphasia' in which people lose or have a severely impaired ability to use language. Speechless tells the powerful stories of two men who can no longer take language for granted. Much of the film is made on the Neuro Rehab Unit of the National Hospital for Neurology and Neurosurgery in London's Queen Square. There, Alwyn meets 55 year old Barry who has been in hospital for 4 months since a stroke left him barely able to speak. Courageous and determined, Barry's personality constantly triumphs where his language fails. And two years after his stroke when just 35 years-old, former Premier League and international footballer Junior Agogo is still visiting the Unit as he battles to find his way in the world with depleted language. “I had thoughts but I'm saying, where was my voice? I was baffled, man.” Speechless raises questions that straddle philosophy and science. Can we understand the world if we don't have language to name and describe it? Can we think without language? How much is our identity wrapped up in language? These questions are at the heart of conversations that Alwyn has with clinicians and therapists working to get Barry and Junior back into the world. Speechless is fascinating and moving, upsetting and uplifting in its depiction of the isolating and estranging condition, aphasia.
2017 • Brain
Could the power of fake pills be used to treat some of our most common medical complaints? To find out, Dr Michael Mosley embarks on Britain's largest ever trial to investigate the placebo effect. He is heading to Blackpool to gather 117 people suffering from backache - one of the leading types of chronic pain - before trying to treat them with nothing but fake pills and the power of the mind. Working with experts from the University of Oxford, Michael discovers that the placebo effect is more than just a medical curiosity. The brain is actually capable of producing its own drugs, and these can be more powerful than prescription painkillers. Michael's volunteers come from all walks of life, but they have all suffered with bad backs for years and feel their conventional medication isn't up to the job. They include Stacey, who is struggling to keep up with her two energetic daughters, wheelchair user Jim, who longs to be able to get back on a boat, and poker player Moyra, who is looking for a painkiller which doesn't affect her performance. They think they are taking part in the trial of a powerful new painkiller, but their blue and white capsules actually contain nothing but ground-up rice. Can this fake treatment make a real difference? And how will the volunteers react when Michael reveals the truth? Michael also finds out about some remarkable placebo experiments from around the world, including a woman in Oxfordshire who experienced a near-miraculous recovery after undergoing fake surgery to fix her chronic shoulder pain. Plus a team in Lancashire who want to see if the placebo effect can cure a broken heart. And Michael discovers a team in Germany working on a placebo that works even if you know you are taking it, which might improve the lives of transplant patients. Michael also tests this out on himself - attempting to train his own body to respond to a fake treatment - a foul-tasting green drink - as if he were taking actual drugs.
The Psychedelic Drug Trial has exclusive access to a ground-breaking new trial at Imperial College London. The trial sees, for the first time ever under controlled conditions, a psychedelic drug tested head-to-head against a standard antidepressant as a treatment for depression. The film follows a pioneering team of scientists and psychotherapists, led by Professor David Nutt, Dr Robin Carhart-Harris and Dr Rosalind Watts, as they compare the effects of psilocybin (the active ingredient of magic mushrooms) with an antidepressant (an SSRI called escitalopram) on a small group of participants with clinical depression. This is scientific research at its most cutting edge. With over seven million people being prescribed antidepressants each year in England alone, this drug trial is an important milestone in understanding a completely different treatment for depression.
2021 • Brain