The Ebola virus. No-one knows exactly where it comes from but one thing is certain - it's one of the most virulent infections known to science. This special episode of Horizon meets the scientists and doctors from all around the world looking for the cure and hears first-hand accounts of what it's actually like to catch - and survive - this terrible disease.
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Thousands of chemicals are used in everyday products – in our water, our food and in the air we breathe. It’s the chemical soup of modern life and it’s virtually impossible to escape them. Is there adequate regulation and testing, or are we in the midst of an uncontrolled, human experiment?
2/10 • Catalyst: Season 1 • 2015 • Health
Of all the diseases that plague humankind, malaria has put up one of the longest, toughest fights. More than 200 million people fall ill and 600,000 die of it every year, making it among the world's deadliest diseases. The vast majority of those fatalities are young children - an average of one child every minute. But medical science may now be at an exciting turning point. Filmed with intimate access to key scientists on four continents, this documentary tells the inside story of the development of a new malaria vaccine that could change the very nature of the fight. It's hoped that the vaccine, dubbed R21/Matrix-M and developed by many of the same team behind the Oxford/AstraZeneca Covid-19 vaccine, will be the first to meet the World Health Organization's target of 75 per cent efficacy.
2024 • Health
After being diagnosed with a rare and deadly form of malignant melanoma - acral lentiginous melanoma - Dr George McGavin embarks on a highly emotional and deeply personal journey as he goes through treatment for his cancer. George’s treatment is targeted drug therapy, using drugs approved for use by the NHS only weeks before his diagnosis. During this journey, he is given unprecedented access to the process and science behind his medical treatment and diagnosis. He also meets some of the most highly regarded scientists in the field of cancer research in his quest to understand not just his disease but what the future holds as a whole for cancer treatment. Amongst them are Professor Sir Michael Stratton, director of the Wellcome Sanger Institute and chief executive officer of the Wellcome Genome Campus, whose work resulted in the discovery of the mutation in the B RAF gene responsible for his form of melanoma. George also travels to Houston, Texas to meet Professor James P Allison, winner of the 2018 Nobel Prize in Medicine, to find out about his pioneering work in the field of immunotherapy - the greatest breakthrough in cancer research in a century. Back home in his own hospital, he meets a unique group of stage four melanoma patients who owe their lives to Professor Allison’s work. Ultimately, his journey culminates when he receives his prognosis, after three months of treatment, which will determine his future. Will these groundbreaking drugs actually work?
2019 • Health
Episode 2 – exposes how the industrial revolution opened the floodgates for highly-processed convenience foods that became "our daily bread." But those pseudo-grains are known to contribute to chronic disease. Natural, whole grains support longevity and lower the risk of heart disease. Grain of Truth also explores the debate over gluten as a dietary evil.
S1E2 • Prescription: Nutrition • 2017 • Health
Horizon investigates a new era of Alzheimer's research, which is bringing hope to millions of sufferers across the world. New scanning and gene technology is allowing scientists to identify the disease at its earliest stages, often 15 years before symptoms appear and the brain cells are destroyed. A series of new drugs trials in Colombia, the USA and Europe are showing startling success in reducing beta amyloid, the protein which is a hallmark of the disease. It is also becoming clear that changes in lifestyle can prevent the development of the disease. A new system inside the brain has been discovered which clears amyloid when we are in deep sleep, but allows it to accumulate if we don't sleep well. The programme reveals that for sufferers in the early stages of the disease, brain connections, or synapses, can be strengthened and even replaced by absorbing enough of the right nutrients. A UK-wide trail helps sufferers in the early stages to concentrate on improving everyday tasks, and in the process not only make their lives easier, but helps to reactivate the planning and organisational parts of the brain. In an ageing world, where the biggest risk of developing Alzheimer's is old age, the scientific breakthroughs in Alzheimer's disease are bringing hope where once there was despair.