How do vaccines work?

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The first ever vaccine was created when Edward Jenner, an English physician and scientist, successfully injected small amounts of a cowpox virus into a young boy to protect him from the related (and deadly) smallpox virus. But how does this seemingly counterintuitive process work? Kelwalin Dhanasarnsombut details the science behind vaccines.

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The Great Plague

Xand van Tulleken, Raksha Dave and John Sergeant discover the parallels of the Great Plague of 1665 with the Covid-19 pandemic. Ch1. Outbreak The epidemic is traced back to its source in the parish of St Giles in the Fields, now at the heart of London's theatre district. The program also examines the symptoms of the disease and uncovers new research into the plague bacteria that could overthrow accepted ideas about how the infection was spread. Ch2. Decimation Xand heads to St Barts hospital to look back at historical records which show that nursing staff stayed behind and risked their lives to help the sick. Elsewhere, John investigates why infection rates were so different between the rich and poor, examining clothes typical for each group in the 17th century. Ch3. Aftermath Xand visits Samuel Pepys' parish church and discovers the sad tale of the Poole family, who within 11 days lost all five of their children. He also heads to Eyam in Derbyshire, revealing the heroic story of self-sacrifice that saw all 700 villagers lock themselves in to try to stop the disease from spreading to surrounding areas. Raksha Dave trials 17th-century disinfection methods and reveal a surprising substitute that can be just as effective as modern antibacterial cleaners.

2020 • Health

Cradle to Grave

An ambitious account of the story of human physiology in a feature-length dramatised documentary. Harnessing the magic of the most modern visual effects, we tell the story of the human body—inside and out—as it lives, grows, and dies on this predestined journey we call life. This unique National Geographic docudrama traces the life of a man, Adam, from the Cradle to the Grave, explaining the science behind our highs and lows, the rites of passage we all go through and exploring the inner workings of our bodies and how they change through time. The 90-year-old narrator, Adam, reflects on his life from conception through boyhood, adolescence and beyond, revealing the events that shape him. Along the way we meet the class bully, Adam's first love and the sergeant major preparing him and fellow recruits for Vietnam. With the aid of stunning computer-generated visuals, we go under the skin to reveal how Adam's body responds to major life events, and his story is told in dramatic scenes from the 1950s to the present day.

2016 • Health

Curing Alzheimer's

Horizon investigates a new era of Alzheimer's research, which is bringing hope to millions of sufferers across the world. New scanning and gene technology is allowing scientists to identify the disease at its earliest stages, often 15 years before symptoms appear and the brain cells are destroyed. A series of new drugs trials in Colombia, the USA and Europe are showing startling success in reducing beta amyloid, the protein which is a hallmark of the disease. It is also becoming clear that changes in lifestyle can prevent the development of the disease. A new system inside the brain has been discovered which clears amyloid when we are in deep sleep, but allows it to accumulate if we don't sleep well. The programme reveals that for sufferers in the early stages of the disease, brain connections, or synapses, can be strengthened and even replaced by absorbing enough of the right nutrients. A UK-wide trail helps sufferers in the early stages to concentrate on improving everyday tasks, and in the process not only make their lives easier, but helps to reactivate the planning and organisational parts of the brain. In an ageing world, where the biggest risk of developing Alzheimer's is old age, the scientific breakthroughs in Alzheimer's disease are bringing hope where once there was despair.

Horizon • 2016 • Health

Controversial Diets

Gloria Hunniford and Chris Bavin investigate the controversial diets that recommend cutting out entire food groups from what you eat. With the experts divided, could some of these quick-fix fads do you more harm than good?

S2E5Food: Truth or Scare • 2017 • Health

Do I Only Use 10% of My Brain?

SciShow debunks the myth that you only use 10 percent of your brain. So, how much do you really use? And how do we know?

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How do vaccines work?

The first ever vaccine was created when Edward Jenner, an English physician and scientist, successfully injected small amounts of a cowpox virus into a young boy to protect him from the related (and deadly) smallpox virus. But how does this seemingly counterintuitive process work? Kelwalin Dhanasarnsombut details the science behind vaccines.

Health