The shape, contents and future of the universe are all intricately related. We know that it's mostly flat; we know that it's made up of baryonic matter (like stars and planets), but mostly dark matter and dark energy; and we know that it's expanding constantly, so that all stars will eventually burn out into a cold nothingness. Renée Hlozek expands on the beauty of this dark ending.
Beginning with the origins of the universe in the Big Bang, Sagan describes the formation of different types of galaxies and anomalies such as galactic collisions and quasars. The episodes moves further into ideas about the structure of the Universe, such as different dimensions (in the imaginary Flatland and four-dimensional hypercubes), an infinite vs. a finite universe, and the idea of an oscillating Universe (similar to that in Hindu cosmology). The search into other ideas such as dark matter and the multiverse is shown, using tools such as the Very Large Array in New Mexico. Cosmos Update shows new information about the odd, irregular surfaces of galaxies and the Milky Way perhaps being a barred spiral galaxy.
Even with a surface temperature of -180C, Saturn's moon, Titan, could be another Earth. There's evidence of dunes made of quantities of organic material that could contain the building blocks for DNA. Astrobiologists are conducting studies on the possibility that life could be present on Titan.