Michael Mosley explores the latest science about how our personalities are created - and whether they can be changed. Despite appearances, Mosley is a pessimist who constantly frets about the future. He wants to worry less and become more of an optimist. He tries out two techniques to change this aspect of his personality - with surprising results. And he travels to the frontiers of genetics and neuroscience to find out about the forces that shape all our personalities.
Surgeon Gabriel Weston discovers the surprising truth about why so many people are piling on the pounds, and how to fight the fat epidemic. She discovers the hidden battles of hormones that control people's appetites, and sees the latest surgery that fundamentally changes what a patient wants to eat by altering how their brains work. Gabriel is shocked to find out that when it comes to being overweight, it is not always your fault you are fat.
For hundreds of years, psychiatry has treated voices and hallucinations as an enemy - regarding them as 'insanity' or 'madness' and seeing them as something to be quashed and even frightened of. But today, new scientific and psychological insights into how the brain works are leading to a radical rethink on what such experiences are - and how they should be treated. Horizon follows three people living with voices, hallucinations and paranoia, to explore what causes this kind of phenomena. Providing a rare first-hand insight into these experiences, they reveal just what it is like to live with them day to day. They examine the impact of social, biological and environmental influences on conditions traditionally associated with insanity, such as schizophrenia and psychosis, and within the film they look at how new ways of understanding the brain are leading to a dramatic change in treatments and approaches, and examine whether targeting the root causes of psychosis can lead to recovery. Above all, they try to uncover why it happened to them - and whether it could happen to you.