Many clinical trials target the nation's most acute health issues. With deaths from liver disease soaring by 40 per cent in a decade, more and more patients are waiting for vital liver transplants. There is a shortage of organ donors and many donated organs are rejected as only those in excellent condition are considered suitable for a transplant procedure. Surgeons Richard Laing and Thamara Perera are part of a team at QEHB trialling a revolutionary way to tackle this crisis, by maximising the number of donor organs that can be safely re-used. The film follows the trial every step of the way, as Richard receives a donor liver that would usually be rejected and tries to prove it is viable for transplant by rejuvenating and testing it on a perfusion machine. This machine sustains the liver by mimicking the supply of blood, oxygen and nutrients an organ receives inside a live, healthy human body. Once the donor liver has proved itself fit for transplant, the surgical team start to remove grandmother Connie O'Driscoll's severely diseased liver. Once the donor liver has been disconnected from the perfusion machine, they have just 20 minutes to place it in Connie's body and plumb it into the complex and delicate network of hepatic blood vessels.
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Specialist maxillofacial surgeons Tim Martin and Sat Parmar prepare for a marathon operation on 53-year-old Teresa. Four weeks ago, Teresa was diagnosed with a fast-growing cancerous tumour in her face and she will die within weeks unless it is removed. The procedure involves radical surgery to the entire right-hand side of her face, and means she will lose both her upper jaw and right eye. It is an enormous undertaking for Teresa, and for Tim and Sat, too. Using 3D imaging, the team plan how to remove the tumour and, most importantly, how they will rebuild Teresa's face. Tim and Sat are all too aware that whilst removing the tumour will save her life, it will be devastating if she is left disfigured and unable to face the world. To give her the best possible outcome, they intend to fill the cavity left in Teresa's face with a section of bone and muscle removed from her hip, using a 3D-printed plastic guide that helps them cut out the correct shape bone.
2018 • Health
Two procedures so formidable, they would not have been attempted even a few years ago. Surgical teams at the Queen Elizabeth are constantly pushing the limits of what is possible. But despite state-of-the-art diagnostic scanning, sometimes cancer surgeons don't know exactly what they are up against until they open the patient up on the operating table. Even with the most meticulous planning, sometimes they must resort to taking critical decisions live in the theatre. 74-year-old Jasmine Harkness has been referred to the specialist sarcoma unit with a vast tumour in her abdomen, weighing more than three stone - a third of her total body weight. It is consuming her, displacing organs including her stomach and liver. Unless it can be removed, she has just four weeks to live. Sarcoma specialists Sam Ford and Professor David Gourevitch can't be sure whether they will be able to save Jasmine until they open her up and inspect her anatomy. Such is the risk of this surgery - five years ago they would not have embarked on this intervention. Sue Sinclair, lead anaesthetist and matriarch of theatre, keeps the others in check - working alongside them as they battle to detach the tumour from Jasmine's organs and blood vessels, and remove it intact. Whenever it presses heavily on vital blood vessels, Jasmine's blood pressure plummets, placing her life in grave danger. It will take unwavering focus to keep her alive. The tumour has grown so invasively that it has crushed and displaced Jasmine's internal organs. Sam and David have a puzzle on their hands to identify what and where everything is. At times, dark humour is the only way to release the tension as they grapple with blood, guts and mind-boggling complexity.
2018 • Health
Many clinical trials target the nation's most acute health issues. With deaths from liver disease soaring by 40 per cent in a decade, more and more patients are waiting for vital liver transplants. There is a shortage of organ donors and many donated organs are rejected as only those in excellent condition are considered suitable for a transplant procedure. Surgeons Richard Laing and Thamara Perera are part of a team at QEHB trialling a revolutionary way to tackle this crisis, by maximising the number of donor organs that can be safely re-used. The film follows the trial every step of the way, as Richard receives a donor liver that would usually be rejected and tries to prove it is viable for transplant by rejuvenating and testing it on a perfusion machine. This machine sustains the liver by mimicking the supply of blood, oxygen and nutrients an organ receives inside a live, healthy human body. Once the donor liver has proved itself fit for transplant, the surgical team start to remove grandmother Connie O'Driscoll's severely diseased liver. Once the donor liver has been disconnected from the perfusion machine, they have just 20 minutes to place it in Connie's body and plumb it into the complex and delicate network of hepatic blood vessels.
2018 • Health
COVID-19 is far from the first pandemic to wreak havoc in the world. A long line of infectious diseases have devastated and in some cases destroyed entire societies. Almost all of them started in animals and made the jump to humans. We are terrified of pandemics. And with good reason. Infectious diseases have cost the lives of countless people over the centuries, devastating families, towns, and even societies. The Black Death spread across Europe and Asia in the 14th century leaving millions dead in its wake. Between the 15th and 18th centuries, European colonists brought smallpox to the Americas, the Pacific region and to Australia. In Europe, the 17th century saw a series of major epidemics. And at the end of the First World War, more people died of the Spanish flu than on the battlefield. This documentary examines the causes of these epidemics - whether it be lack of hygiene, interaction with animals, overcrowding, or the growth of cities - and how people travelling helped to spread disease and promote pandemics. It also sheds a light on the impact these infectious diseases have had on politics and societal change. Today, the world is facing COVID-19. Measures such as quarantine and lockdowns are being rolled out in an effort to control the spread of the virus; and, just as our ancestors did before us, some are questioning how effective they are. Over the centuries, scientists managed to develop treatments and medicines to help control or even eradicate infectious diseases. Virologists are facing that task again with the coronavirus, as the world frantically searches for ways to overcome a pandemic which threatens our modern way of life.
2020 • Health
Psychopaths have long captured the public imagination. Painted as charismatic, violent predators lacking in all empathy, they provide intrigue and horror in equal measure. But what precisely is a psychopath? What is it that drives them to cause harm, even kill? And can they ever be cured? Presented by psychologist professor Uta Frith, this is an in-depth exploration of the psychopathic mind including one of the most notorious of all, Moors murderer Ian Brady. Through an ongoing correspondence between the Horizon team and Brady, the film features some of the very last letters he wrote. The film also features a series of candid interviews with prison inmates who not only describe their crimes but why they think they committed them. Horizon explores not only how each individual's crimes were shaped by their own life experiences, but also gives an insight into how these people think and behave. Working with the world's experts in the field, the film sheds light on the biological, psychological and environmental influences that shape a psychopath. And it looks to the future, with groundbreaking research that suggests a lifetime of incarceration is not the only option to manage violent and dangerous psychopaths.
Surgeon Gabriel Weston discovers the surprising truth about why so many people are piling on the pounds, and how to fight the fat epidemic. She discovers the hidden battles of hormones that control people's appetites, and sees the latest surgery that fundamentally changes what a patient wants to eat by altering how their brains work. Gabriel is shocked to find out that when it comes to being overweight, it is not always your fault you are fat.
Brain researcher Jill Bolte Taylor studied her own stroke as it happened -- and has become a powerful voice for brain recovery.
2012 • Health
How can people live so long and with such great health? A trip to Okinawa reveals simple secrets about diet, lifestyle and longevity. They maintain a sense of purpose no matter what age and you won't find them laying on the sofa.
S1E1 • Live to 100: Secrets of the Blue Zones • 2023 • Health