A Year to Save My Life: George McGavin and Melanoma • 2019

58:39

Horizon investigates a new era of Alzheimer's research, which is bringing hope to millions of sufferers across the world. New scanning and gene technology is allowing scientists to identify the disease at its earliest stages, often 15 years before symptoms appear and the brain cells are destroyed. A series of new drugs trials in Colombia, the USA and Europe are showing startling success in reducing beta amyloid, the protein which is a hallmark of the disease. It is also becoming clear that changes in lifestyle can prevent the development of the disease. A new system inside the brain has been discovered which clears amyloid when we are in deep sleep, but allows it to accumulate if we don't sleep well. The programme reveals that for sufferers in the early stages of the disease, brain connections, or synapses, can be strengthened and even replaced by absorbing enough of the right nutrients. A UK-wide trail helps sufferers in the early stages to concentrate on improving everyday tasks, and in the process not only make their lives easier, but helps to reactivate the planning and organisational parts of the brain. In an ageing world, where the biggest risk of developing Alzheimer's is old age, the scientific breakthroughs in Alzheimer's disease are bringing hope where once there was despair.

Horizon • 2016 • Health

58:28

Many clinical trials target the nation's most acute health issues. With deaths from liver disease soaring by 40 per cent in a decade, more and more patients are waiting for vital liver transplants. There is a shortage of organ donors and many donated organs are rejected as only those in excellent condition are considered suitable for a transplant procedure. Surgeons Richard Laing and Thamara Perera are part of a team at QEHB trialling a revolutionary way to tackle this crisis, by maximising the number of donor organs that can be safely re-used. The film follows the trial every step of the way, as Richard receives a donor liver that would usually be rejected and tries to prove it is viable for transplant by rejuvenating and testing it on a perfusion machine. This machine sustains the liver by mimicking the supply of blood, oxygen and nutrients an organ receives inside a live, healthy human body. Once the donor liver has proved itself fit for transplant, the surgical team start to remove grandmother Connie O'Driscoll's severely diseased liver. Once the donor liver has been disconnected from the perfusion machine, they have just 20 minutes to place it in Connie's body and plumb it into the complex and delicate network of hepatic blood vessels.

S1E3 • Surgeons: At the Edge of Life • 2018 • Health

45:02

Obesity is one of America's biggest public health concerns. Two thirds of Americans are overweight or obese. The pressure to lose weight is intense and many are turning to surgical means to achieve results.

S1E4 • A User's Guide to Cheating Death • 2017 • Health

45:59

It was 1952, and polio had reached outbreak levels in America. There was no known cause, no cure, and no help in sight for parents desperate to protect their children. Our nation's hope was placed in a 33-year-old scientist, working from a basement lab in Pittsburgh. His name was Jonas Salk, and in just a few years, he would bring infantile paralysis to its knees and change the course of medical history. Travel back to a world gripped in fear and see how Dr. Salk, with his dedicated staff, a young charity, and a faithful nation, came together to conquer polio.

2010 • Health

59:18

The Ebola virus. No-one knows exactly where it comes from but one thing is certain - it's one of the most virulent infections known to science. This special episode of Horizon meets the scientists and doctors from all around the world looking for the cure and hears first-hand accounts of what it's actually like to catch - and survive - this terrible disease.

Health

4:00

Our skin is the largest organ in our bodies, with a surface area of about 20 square feet in adults. When we are cut or wounded, our skin begins to repair itself through a complex, well-coordinated process. Sarthak Sinha takes us past the epidermis and into the dermis to investigate this regenerative response.

TED-Ed • Health