Why Diets Fail • 2018 • episode "S1E6" • Explained

42:59

As winter sets in, US Rangers must capture Hill 400, a strategic peak on the German border.

3/4 • Hitler's Last Stand • 2018 • Health

56:58

Documentary using visual effects and CGI to examine the effects of ecstasy on the body.

2/3 • How Drugs Work • Health

45:02

Obesity is one of America's biggest public health concerns. Two thirds of Americans are overweight or obese. The pressure to lose weight is intense and many are turning to surgical means to achieve results.

4/6 • A User's Guide to Cheating Death • 2017 • Health

87:22

As a woman in New York City leans over a table, about to inhale a line of cocaine, she is unknowingly part of a $30 billion a year industry — an illegal empire governed by fear and violence, bribery and corruption, all spiraling out of control and turning Mexico and the southern border of the United States into one of the deadliest places on earth. In this probing, incisive investigation into the bloodstained path taken by cocaine we travel backwards from the end user in the U.S. all the way to the drug's source high in the South American mountains. We meet the dealers, traffickers, smugglers and farmers who together form its production and distribution chain, as well as the law enforcement agencies and individuals whose mission is to shut the deadly trade down. The cocaine industry is littered with unimaginable sums of cash and more than 35,000 murders in the past five years. Much of this violence occurs on the border between the United States and Mexico. This is just one aspect of the cocaine epidemic which is explored in the feature-length documentary Cocaine: History Between the Lines. This two-hour special goes inside the history of the second most used illicit drug in America. The human appetite for this narcotic goes all the way back to 3000 B.C., when South Americans chewed coca leaves thinking they were a gift from God. But it wasn't until 1855, when cocaine was first extracted from the coca leaf and used in powder form that its use spiked. Initially it was utilized as an anesthesia. Soon, famed psychologist Sigmund Freud touted it as an effective cure for depression and impotence. In 1886, John Pemberton, an Atlanta pharmacist, added it to his new soft drink: Coca Cola or Coke for short. In 1914, the drug was outlawed, but the damage had been done. The 70's ushered in another boost in the drug's use fueled in part by new drug cartels in South America. To combat cocaine's rise, the Reagan administration started the War on Drugs in the 80's. That hasn't stopped the proliferation of the drug in cities across America or with the cartels that continue to feed at the trough of this $30 billion dollar a year business. Cocaine use may have peaked decades ago, but it's never gone away. With the advent of crack cocaine in the 1980s, the trade became deadlier and more toxic than ever before. The high demand for the product has rendered more than 70% of Mexico under the control of the smuggling trade. American law enforcement agencies from Texas to California are fearful that this nefarious element will soon enter their country unchallenged. According to the officers interviewed in the film, border security is lax, and bureaucrats in Washington are doing little to remedy the crisis. For them, the discovery of a dismembered body – whether it be a trafficker, illegal immigrant or innocent bystander - has become a daily occurrence. This harsh reality is lost on most of the users themselves, who run the gamut from the hippest clubbers to the homeless population across America. Each user profiled in the film shares their experiences with the alluring white powder. Whether they use the drug recreationally or habitually, they have all witnessed the hold it can have on a life. From the personal to the political, Cocaine: History Between the Lines is a comprehensive account of a drug that has left much devastation in its wake.

2011 • Health

100:14

Follows two patients through groundbreaking 'first in-human' trials for CAR T-cell therapy, a treatment described as the beginning of the end of cancer. Not allowed to meet and separated by two floors of a hospital, 53-year-old Graham and 18-year old-Mahmoud are nevertheless bound together by their commitment to the treatment and their faith in the science. Terminally ill, the trial represents their only option. How do their ages and life experiences affect their physical and emotional response? For Martin Pule, the scientist who has developed the treatment, the responsibility of curing patients is both exciting and daunting. He knows he stands on the cusp of a breakthrough that could radically change the way we treat cancer. At the heart of this film is the complex relationship between the patients and the clinical team. How much hope can the patients be given when they are effectively going into these trials as human guinea pigs? The patients and clinical team must weigh up hope with realism and their response is a profound and revealing reflection of the human condition.

2019 • Health

58:48

Our lifespan is increasing by 2.5 years every decade - and a third of all babies born today can expect to live to 100. But living longer can come at a cost. Old age itself brings with it a range of debilitating illnesses, many of which are the result of accumulating damage during our lifetime. Three diseases in particular have become the main killers in the developed world - cancer, heart disease and dementia. But a revolution in bio-medicine is now offering new hope for the treatment of these ailments, and the potential to extend our lives still further. Methods such as gene editing and stem cell therapies are transforming the way medicine can conquer disease today. These extreme frontiers of medicine do, however, also come with a range of ethical dilemmas - when is the right time to try out an experimental technique on a patient? Should we gene edit human embryos? And is it right to use cells from aborted foetuses for medical treatments?

Big Think • 2017 • Health